859947-04-9Relevant academic research and scientific papers
Nucleophilic addition reaction with dearomatization of naphthalene ring
Imayoshi, Ayumi,Kiyotaki, Kotaro,Sasaki, Hirotaka,Tsubaki, Kazunori
, p. 384 - 391 (2020)
Various aromatic lactones have been synthesized and their regioselectivity (1,2-addition vs. 1,4- or 1,6-addition) investigated in reactions with organolithium species, particularly n-BuLi and sec-BuLi. The regioselectivity varied greatly depending on various factors, such as the bulkiness of both substrates and organolithium species, and types of solvent and cosolvent. In particular, 1,4-addition with dearomatization occurred preferentially using sec-BuLi as the nucleophile in tetrahydrofuran (THF) with hexamethylphosphoramide (HMPA) or N,N′-dimethylpropyleneurea (DMPU) as cosolvent. For sec-BuLi, the reaction was estimated to proceed through a single-electron transfer mechanism.
