86-80-6

Usage

Therapeutic Function

Local anesthetic

InChI:InChI=1/C17H24N2O/c1-4-5-9-15-13-14-8-6-7-10-16(14)17(18-15)20-12-11-19(2)3/h6-8,10,13H,4-5,9,11-12H2,1-3H3

Upstream product

• 37616-36-7 sodium N,N-dimethylethanolamine 
• 87-06-9 3-butyl-1-chloro-isoquinoline 
• 185427-48-9 [(((CH₃)4C₂O₂)B)(C₄H₉)CCH(B(O₂C₂(CH₃)4))] 
• 693-02-7 hex-1-yne 
• 428845-57-2 2-(dimethylamino)ethyl 2-bromobenzoate 
• 132-90-1 3-butyl-isoquinolin-1-ol 

Relevant academic research and scientific papers

Synthesis of Polysubstituted Isoquinolines and Related Fused Pyridines from Alkenyl Boronic Esters via a Copper-Catalyzed Azidation/Aza-Wittig Condensation Sequence

An efficient and straightforward synthesis of isoquinolines is reported from internal alkenyl boronic esters, easily prepared from the corresponding 1,2-bis(boronates), via a sequential copper-catalyzed azidation/aza-Wittig condensation. This synthetic method has been used to synthesize quinisocaine, a topical anesthetic used for the treatment of pain and pruritus, and further extended to thieno[2,3-c]pyridines by using 2-thiophenecarboxaldehyde as coupling partner in the first step.