860000-78-8

Basic information

• Product Name: methyl 2-benzyloxy-5-bromo-benzoate
• CAS NO: 860000-78-8
• Molecular Formula: C₁₅H₁₃BrO₃
• Molecular Weight: 321.1659
• Mol File: 860000-78-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 409.795°C at 760 mmHg
• Flash Point: 201.637°C
• Density: 1.407g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: methyl 2-benzyloxy-5-bromo-benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-benzyloxy-5-bromo-benzoate(860000-78-8)
• EPA Substance Registry System: methyl 2-benzyloxy-5-bromo-benzoate(860000-78-8)

Safety Data

• Hazardous Substances Data: 860000-78-8(Hazardous Substances Data)

Usage

General Description

Methyl 2-benzyloxy-5-bromo-benzoate is a derivative of benzoic acid with a methyl ester group at one end and a benzyl ether group attached to the benzoate ring. It also contains a bromine atom at the 5-position of the benzoate ring. This chemical is commonly used in organic synthesis as a building block for the production of various pharmaceuticals, agrochemicals, and other specialty chemicals. It can undergo various reactions, including esterification and nucleophilic substitution, making it a versatile compound for the synthesis of complex molecules. Additionally, the benzyl ether group can be selectively cleaved under specific conditions, allowing for further manipulation of the molecule. Overall, methyl 2-benzyloxy-5-bromo-benzoate plays a crucial role in the development of new chemical compounds for a range of applications.

Upstream product

• 4068-76-2 5-bromo-2-hydroxy-benzoic acid methyl ester 
• 100-39-0 benzyl bromide 
• 79670-17-0 methyl 2-bromomethyl-5-bromobenzoate 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1352042-52-4 ethyl (E)-3-carbomethoxy-4-hydroxycinnamate 
• 1352042-53-5 ethyl (E)-3-carbomethoxy-4-trifluoromethylsulfonyloxycinnamate 
• 1352042-57-9 ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-carbomethoxycinnamate 
• 1352042-62-6 ethyl (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-carbomethoxycinnamate 
• 1352042-68-2 (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-(methoxycarbonyl)cinnamic acid 
• 1352042-69-3 (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-carboxycinnamic acid 
• 1352042-51-3 ethyl (E)-4-benzyloxy-3-carbomethoxycinnamate 
• 1160249-51-3 C₁₄H₁₀BrClO₂ 
• 1616373-16-0 methyl 2-(3-(benzyloxy)-3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)-[1,1'-biphenyl]-4-yl)acetate 
• 862082-12-0 2-benzyloxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid methyl ester 

Relevant articles and documents

Metal-free Synthesis of Spiro-2,2′-benzo[b]furan-3,3′-ones via PhI(OAc)2-Mediated Cascade Spirocyclization

Treating the benzyl protected 3-hydroxy-1,3-bis(2-hydroxyphenyl)prop-2-en-1-ones solely with PhI(OAc)2 (PIDA) in DCE at room temperature readily furnished the seldom studied spiro-2,2′-benzo[b]furan-3,3′-ones in satisfactory to excellent yields. The hypervalent iodine reagent enables the metal-free cascade spirocyclization resulting in the dual oxidative C?O bond formation. (Figure presented.).

Analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. 2. Impact of 3-chloro group replacement on inhibition of proliferation and induction of apoptosis of

The parent phenol of adapalene and its (E)-cinnamic acid analogue were found to induce cancer cell apoptosis but cause adverse systemic effects when administered to mice. In contrast, their respective 5-Cl- and 3-Cl-substituted analogues had their adverse