860013-16-7

Basic information

• Product Name: N-(N-carbobenzyloxy-L-alanyl)-(2S)-2-phenylglycine tert-butyl ester
• Synonyms: N-(N-carbobenzyloxy-L-alanyl)-(2S)-2-phenylglycine tert-butyl ester
• CAS NO: 860013-16-7
• Molecular Weight: 412.486
• Mol File: 860013-16-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-(N-carbobenzyloxy-L-alanyl)-(2S)-2-phenylglycine tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(N-carbobenzyloxy-L-alanyl)-(2S)-2-phenylglycine tert-butyl ester(860013-16-7)
• EPA Substance Registry System: N-(N-carbobenzyloxy-L-alanyl)-(2S)-2-phenylglycine tert-butyl ester(860013-16-7)

Safety Data

• Hazardous Substances Data: 860013-16-7(Hazardous Substances Data)

Upstream product

• 2935-35-5 (S)-2-phenylglycine 
• 1142-20-7 N-Cbz-Ala 

Downstream Products

• 327052-53-9 N-(L-alanyl)-(2S)-2-phenylglycine tert-butyl ester 
• 867021-96-3 N-[N-(tert-butyloxycarbonyl)-L-alanyl]-(2S)-2-phenylglycine 
• 867022-09-1 6-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-2-phenyl-acetylamino]-hexanoic acid (S)-2-((R)-3,4-bis-benzyloxy-5-oxo-2,5-dihydro-furan-2-yl)-2-hydroxy-ethyl ester 
• 208255-80-5 ((S)-tert-butyl 2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate) 
• 263162-50-1 (2S)-({N-[(3,5-difluorophenyl)acetyl]-L-alanyl}amino)(phenyl)acetic acid 

Relevant articles and documents

Epimerization-Free C-Term Activation of Peptide Fragments by Ball Milling

Peptides were produced in high yields and, if any, very low epimerization, by mechanochemical coupling of peptide fragments containing highly epimerization-prone and/or highly hindered amino acids at C-term. Ball milling was clearly identified as the key element enabling one to obtain such results.

Design of β-secretase inhibitors by introduction of a mandelyl moiety in DAPT analogues

We report the synthesis of two series of compounds with 3,5-difluoromandelyl-alanyl or 3,5-difluorophenylacetylalany1 backbones coupled to various heterocyclic or peptidic moieties. These two series of compounds were evaluated for their inhibitory propert