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Usage

Uses

Used in Organic Synthesis:
4-Methoxy-2-nitrophenylboronic acid is used as a reagent in organic synthesis for its ability to participate in Suzuki coupling reactions. This reaction is a type of cross-coupling process that allows the formation of carbon-carbon bonds, which is crucial in the synthesis of various organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-Methoxy-2-nitrophenylboronic acid is used as a building block for the development of new drugs. Its ability to form complex molecules makes it a valuable tool in the synthesis of potential therapeutic agents.
Used in Material Science:
4-Methoxy-2-nitrophenylboronic acid is also utilized in material science for the synthesis of advanced materials with specific properties. Its involvement in the formation of complex molecules can contribute to the development of new materials with improved characteristics for various applications.
Used in Academic Research:
In academic research, 4-Methoxy-2-nitrophenylboronic acid serves as a valuable compound for studying various chemical reactions and mechanisms. Its unique structure and reactivity make it an interesting subject for exploration in the field of chemistry.

InChI:InChI=1/C7H8BNO5/c1-14-5-2-3-6(8(10)11)7(4-5)9(12)13/h2-4,10-11H,1H3

Upstream product

• 121-43-7 Trimethyl borate 
• 58755-70-7 1-iodo-4-methoxy-2-nitrobenzene 
• 96042-30-7 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran 
• 100-58-3 phenylmagnesium bromide 

Relevant academic research and scientific papers

Promoting reductive tandem reactions of nitrostyrenes with Mo(CO)6 and a palladium catalyst to produce 3 h -indoles

The combination of Mo(CO)6 and 10 mol % of palladium acetate catalyzes the transformation of 2-nitroarenes to 3H-indoles through a tandem cyclization-[1,2] shift reaction of in situ generated nitrosoarenes. Mo(CO)6 appears to have dual roles in this transformation: generate CO and promote C-N bond formation to increase the yield of the N-heterocycle product.

Macrocyclic Compounds As Antiviral Agents

A class of macrocyclic compounds of formula (I), wherein R1, R3, R4, Ra, Rb, A, Z, Y, X, M, W, n and m are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes 5 for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection. Formula (I):

MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS

Inhibitors of HCV replication of formula (I) and the N-oxides, salts, or stereoisomers thereof, wherein each dashed line (represented by ------) represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is -OR6, -NH-SO2R7; R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl; R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, or C3-7cycloalkyl; n is 3, 4, 5, or 6; R4 and R5 independently from one another are hydrogen, halo, hydroxy, nitro, cyano, carboxyl, C1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl, C1-6alkylcarbonyl, C1-6alkoxy- carbonyl, amino, azido, mercapto, C1-6alkylthio, polyhaloC1-6alkyl, aryl or Het; W is aryl or Het; R6 is hydrogen; aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; R7 is aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; aryl is phenyl or naphthyl, each optionally substituted with 1-3 substituents; Het is a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1 - 4 heteroatoms each independently selected from N, O or S, and optionally substituted with 1 -3 substituents; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I). Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.