860194-12-3

Upstream product

• 22751-23-1 (2-nitrophenyl)acetyl chloride 
• 24220-92-6 1-benzylquinolin-4(1H)-one 
• 1620385-50-3 C₁₅H₁₅INO₂⁽¹⁺⁾*CF₃O₃S^(1-) 
• 87-25-2 2-ethoxycarbonylaniline 
• 313528-26-6 3-(2-nitro-phenyl)-quinoline-2,4-diol 
• 28565-97-1 N-(2-nitro-phenylacetyl)-anthranilic acid ethyl ester 

Downstream Products

• 239-09-8 11H-indolo[3,2-c]quinoline 

Relevant academic research and scientific papers

Substrate or Solvent-Controlled PdII-Catalyzed Regioselective Arylation of Quinolin-4(1H)-ones Using Diaryliodonium Salts: Facile Access to Benzoxocine and Aaptamine Analogues

Regioselective C3, C5, and C8 arylation of quinolin-4(1H)-ones have been accomplished either by substrate-control or by tuning the reaction solvent. A variety of aryl(mesityl)iodonium triflates could smoothly deliver arylated products in good to excellent yields. Additionally, it offers great flexibility by arylating medicinally potent quinolone related heterocycles such as acridin-9(10H)-one, and phenanthridin-6(5H)-one under standard reaction conditions. This strategy was further extended with diphenyleneiodonium triflate to access oxacine fused quinolines. The post-modifications of synthesized products enhance the further utility of this protocol in organic synthesis. To the best of our knowledge, this is the first report on C5 arylation of quinolin-4(1H)-ones using iodine(III) reagents.