860299-08-7Relevant academic research and scientific papers
1,6- And 1,7-naphthyridines. IV. Synthesis of hydroxycarboxamide derivatives
Blanco, M. Mercedes,Schapira, Celia B.,Levin, Gustavo,Perillo, Isabel A.
, p. 493 - 502 (2005)
A series of 8-hydroxy-1,6-naphthyridin-5(6H)-one-7-carboxamides 1 and the isomeric 5-hydroxy-1,7-naphthyridin-8(7H)-one-6-carboxamides 2 were synthesized. N-Lactam unsubstituted compounds 1a-c and 2a,b were obtained by alkoxide-induced rearrangement of the corresponding quinolinimidoacetamides 3. Compounds 1e,f and 2e,f were synthesized by heterocyclization of the corresponding quinolinamic esters 6 and 7. Spectroscopic properties (uv, ir, 1H and 13C nmr and ms) were analyzed and the proposed structures confirmed.
