860304-23-0Relevant academic research and scientific papers
Enantioselective synthesis of β-fluoroamines from β-amino alcohols: Application to the synthesis of LY503430
Duthion, Beranger,Pardo, Domingo Gomez,Cossy, Janine
supporting information; experimental part, p. 4620 - 4623 (2010/12/19)
N,N-Dialkyl-β-amino alcohols were enantiospecifically and regioselectively rearranged by using N,N-diethylaminosulfur trifluoride (DAST) to give optically active β-fluoroamines in excellent yields and enantiomeric excesses. This rearrangement was applied to the enantioselective synthesis of LY503430, a potential therapeutic agent for Parkinson's disease.
Synthesis of enantiomerically pure (+)- and (-)-protected 5-aminomethyl-1,3-oxazolidin-2-one derivatives from allylamine and carbon dioxide
Fernandez, Isabelle,Munoz, Luis
, p. 2548 - 2557 (2007/10/03)
The stereoselective synthesis of enantiomerically pure (5R)- and (5S)-aminomethyl-oxazolidinones with different protecting groups have been carried out from an allyl amine as the source of the carbon backbone. The key reaction is the high yield iodiocyclization of enantiomerically pure allylphenethyl amine in the presence of carbon dioxide.
Functionalized pyrrolidines inhibit α-mannosidase activity and growth of human glioblastoma and melanoma cells
Fiaux, Hélène,Popowycz, Florence,Favre, Sylvain,Schütz, Catherine,Vogel, Pierre,Gerber-Lemaire, Sandrine,Juillerat-Jeanneret, Lucienne
, p. 4237 - 4246 (2007/10/03)
New substituted pyrrolidine-3,4-diol derivatives were prepared from D-(-)- and L-(+)-phenyl glycinol. The influence of the configuration and the substitution of the lateral side chain of these derivatives on the inhibition of 25 commercial glycosidases we
