86043-24-5Relevant articles and documents
Possible Anthelmintic Agents: Syntheses of 1,3-Disubstituted 1,2,3,4-Tetrahydro-9H-pyridoindoles and 6,8-Disubstituted 7,8,9,14b-Tetrahydro-14H-quinazolinopyridoindoles
Kumar, Shiv,Roy, Jalpana,Seth, M.,Bhaduri, A. P.
, p. 54 - 59 (2007/10/02)
Pictet-Spengler reaction of tryptophan methyl ester with aromatic and heterocyclic aldehydes gives 1-substituted 3-carbomethoxy-1,2,3,4-tetrahydro-9H-pyridoindoles (1 - 9).Ring closure of 1-(o-aminophenyl)-3-carbomethoxy-1,2,3,4-tetrahydro-9H-pyridoindole (26) or its hydrazide (28) with N-methoxycarbonyl-S-methylisothiourea gives 6,8-disubstituted 7,8,9,14b-tetrahydro-14H-quinazolinopyridoindoles (34 and 29, respectively).The former class of compounds exhibit activity (60 - 86percent) of worm clearance against A. ceylanicum in hamsters whilea member of the latter class of compounds (34) exhibits 100percent of activity only against H. nana at 250 mg/kg in mice.Other compounds which exhibit worm clearance of less than 50percent have not been reported here.