86043-25-6

Basic information

• Product Name: C₂₄H₂₅N₅O₅
• CAS NO: 86043-25-6
• Molecular Weight: 463.493
• Mol File: 86043-25-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₂₅N₅O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₂₅N₅O₅(86043-25-6)
• EPA Substance Registry System: C₂₄H₂₅N₅O₅(86043-25-6)

Safety Data

• Hazardous Substances Data: 86043-25-6(Hazardous Substances Data)

Upstream product

• 7303-49-3 DL-tryptophan methyl ester 
• 528524-76-7 methyl 1-(3-nitrophenyl)-1,2,3,4-tetrahydro-9H-β-carboline-3-carboxylate 
• 86043-19-8 2-Acetyl-1-(3-nitro-phenyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester 
• 99-61-6 3-nitro-benzaldehyde 
• 39259-32-0 methyl N-(1-methylthio-1-iminomethyl)-carbamate 
• 86043-22-3 2-Acetyl-1-(3-amino-phenyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester 

Relevant articles and documents

Possible Anthelmintic Agents: Syntheses of 1,3-Disubstituted 1,2,3,4-Tetrahydro-9H-pyridoindoles and 6,8-Disubstituted 7,8,9,14b-Tetrahydro-14H-quinazolinopyridoindoles

Pictet-Spengler reaction of tryptophan methyl ester with aromatic and heterocyclic aldehydes gives 1-substituted 3-carbomethoxy-1,2,3,4-tetrahydro-9H-pyridoindoles (1 - 9).Ring closure of 1-(o-aminophenyl)-3-carbomethoxy-1,2,3,4-tetrahydro-9H-pyridoindole (26) or its hydrazide (28) with N-methoxycarbonyl-S-methylisothiourea gives 6,8-disubstituted 7,8,9,14b-tetrahydro-14H-quinazolinopyridoindoles (34 and 29, respectively).The former class of compounds exhibit activity (60 - 86percent) of worm clearance against A. ceylanicum in hamsters whilea member of the latter class of compounds (34) exhibits 100percent of activity only against H. nana at 250 mg/kg in mice.Other compounds which exhibit worm clearance of less than 50percent have not been reported here.