86046-45-9

Basic information

• Product Name: 4-(2-Benzo[1,3]dioxol-5-yl-3-methyl-oxazolidin-5-yl)-phenol
• CAS NO: 86046-45-9
• Molecular Weight: 299.326
• Mol File: 86046-45-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-Benzo[1,3]dioxol-5-yl-3-methyl-oxazolidin-5-yl)-phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Benzo[1,3]dioxol-5-yl-3-methyl-oxazolidin-5-yl)-phenol(86046-45-9)
• EPA Substance Registry System: 4-(2-Benzo[1,3]dioxol-5-yl-3-methyl-oxazolidin-5-yl)-phenol(86046-45-9)

Safety Data

• Hazardous Substances Data: 86046-45-9(Hazardous Substances Data)

Upstream product

• 532-80-9 synephrine 
• 120-57-0 piperonal 
• 86046-46-0 [2-(Benzo[1,3]dioxol-5-yl-methoxy-methoxy)-2-(4-hydroxy-phenyl)-ethyl]-methyl-carbamic acid 2,2,2-trichloro-ethyl ester 

Downstream Products

• 86046-48-2 [2-(Benzo[1,3]dioxol-5-yl-methoxy-methoxy)-2-(4-hydroxy-phenyl)-ethyl]-methyl-carbamic acid methyl ester 

Relevant articles and documents

Phenolic Oxidative Coupling with Hypervalent Iodine. A Synthesis of 6a-Epipretazettine

6a-Epipretazettine was synthesized in seven steps from piperonal and synephrine.Intramolecular, monophenolic, oxidative coupling of a functionalized benzylic acetal, employing benzene as oxidant, gave a spirodienone in 13 percent yield.Subsequent deprotection of the secondary amine was followed by spontaneous closure to a tetracyclic pyrrolidine possessing an all-cis ring fusion.This substance was reduced with diisobutylaluminum hydride, and the resulting alcohol was transformed, via methanolysis of the corresponding mesylate, to O-methyl-6a-epipretazettine.Acidic hydrolysis of the latter yielded 6a-epipretazettine, identical with material previously obtained by Danishefsky.