860477-26-5Relevant academic research and scientific papers
Total synthesis of (-)-dictyostatin, a microtubule-stabilising anticancer macrolide of marine sponge origin
Paterson, Ian,Britton, Robert,Delgado, Oscar,Gardner, Nicola M.,Meyer, Arndt,Naylor, Guy J.,Poullennec, Karine G.
experimental part, p. 6534 - 6545 (2010/10/03)
An efficient convergent synthesis of the anticancer marine macrolide (-)-dictyostatin is described that proceeds in 4.6% yield over 27 steps. Most of the stereocentres were configured using substrate control, making use of a common building block to insta
Total synthesis of (-)-dictyostatin
O'Neil, Gregory W.,Phillips, Andrew J.
, p. 5340 - 5341 (2007/10/03)
A convergent total synthesis of dictyostatin is described. Key features of the synthesis include the use of titanium-mediated cyclizations of (silyloxy)enynes for the synthesis of stereotriads, a subunit coupling by metathesis, and macrocyclization by int
METHODS FOR THE SYNTHESIS OF DICTYOSTATIN AND DERIVATIVES AND ANALOGUES THEREOF, STEREOCHEMICAL CHARACTERISATION, NOVEL DICTYOSTATIN COMPOUNDS AND USES THEREOF AND SYNTHETIC INTERMEDIATES
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Page/Page column 47-48; 145-146, (2010/02/13)
A method for the synthesis of dictyostatin or a derivative thereof having Formula (I) is provided.
Total synthesis and configurational assignment of (-)-dictyostatin, a microtubule-stabilizing macrolide of marine sponge origin
Paterson, Ian,Britton, Robert,Delgado, Oscar,Meyer, Arndt,Poullennec, Karine G.
, p. 4629 - 4633 (2007/10/03)
A flexible and modular approach was used in the convergent and highly stereocontrolled synthesis of the antimitotic agent dictyostatin. This first total synthesis establishes its full stereochemistry and should be amenable to producing useful quantities a
