860554-30-9Relevant academic research and scientific papers
A practical oxidative conversion of aldehydes into N-chloroaldimines
Jin, Can,Wang, Feng,Sun, Bin,Zhuang, Xiaohui
, p. 547 - 551 (2018/11/27)
A novel method for the preparation of N-chloroaldimines from commonly available aromatic aldehydes has been developed. The reaction proceeded effectively by two steps: aldehydes were initially transformed into imines and then chloro-substitution with NaClO2 gave the N-chloroaldimines. This simple protocol allows for the preparation of a variety of aromatic N-chloroaldimines in moderate to excellent yields without the isolation of the imine intermediate. We also found that 3-nitrobenzaldehyde and 4-cyanobenzaldehyde were converted into the related benzonitrile directly under the standard conditions.
A Mechanochemical-Assisted Oxidation of Amines to Carbonyl Compounds and Nitriles
Gaspa, Silvia,Porcheddu, Andrea,Valentoni, Antonio,Garroni, Sebastiano,Enzo, Stefano,De Luca, Lidia
supporting information, p. 5519 - 5526 (2017/09/06)
A mild, efficient, metal- and solvent-free oxidation of primary amines to aldehydes, ketones, and nitriles under ball-milling conditions is presented. This method has proved to be compatible with various functional groups and only requires easily accessible starting materials. Simple purification of the reaction mixtures by short-column chromatography afforded pure aldehydes, ketones, and nitriles as products.
