860611-52-5Relevant academic research and scientific papers
New Heterocyclic Hepatitis C Virus (HCV) Inhibitors Containing A 2-Aminomethyl-1H-Indole Fragment
Ivachtchenko,Yamanushkin,Mitkin,Ezhova,Korzinov,Bulanova,Bichko,Ivashchenko
, p. 352 - 361 (2015)
A focused library of heterocyclic compounds including a 2-aminomethyl-1H-benzimidazole (1 19), 2-aminomethylindole (20 83), benzofuran-2-ylmethylamine (84 92), or 2-piperazin-1-ylmethylbenzoxazole (93) fragment was screened for the ability to inhibit in v
Design, synthesis and evaluation of 3-phenoxypyrazine-2-carboxamide derivatives as potent TGR5 agonists
Chen, Wei-Dong,Fu, Yajie,Hou, Ruifang,Li, Yunfu,Wang, Chenwei,Wang, Jie,Wang, Le,Wang, Yan-Dong,Yang, Dongbin,Zhao, Shizhen,Zheng, Shaowei
, p. 3618 - 3629 (2022/02/11)
TGR5 is emerging as an important and promising target for the treatment of non-alcoholic steatohepatitis, type 2 diabetes mellitus (T2DM), and obesity. A series of novel 3-phenoxypyrazine-2-carboxamide derivatives were designed, synthesized and evaluated
