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860617-64-7

5-bromo-2-oxo-3-phenyl-2,3-dihydro-benzoimidazole-1-carboxylic acid tert-butyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 860617-64-7 Structure

  • Basic information

    1. Product Name: 5-bromo-2-oxo-3-phenyl-2,3-dihydro-benzoimidazole-1-carboxylic acid tert-butyl ester
    2. Synonyms:
    3. CAS NO:860617-64-7
    4. Molecular Formula:
    5. Molecular Weight: 389.249
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 860617-64-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-bromo-2-oxo-3-phenyl-2,3-dihydro-benzoimidazole-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-bromo-2-oxo-3-phenyl-2,3-dihydro-benzoimidazole-1-carboxylic acid tert-butyl ester(860617-64-7)
    11. EPA Substance Registry System: 5-bromo-2-oxo-3-phenyl-2,3-dihydro-benzoimidazole-1-carboxylic acid tert-butyl ester(860617-64-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 860617-64-7(Hazardous Substances Data)

860617-64-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 860617-64-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,0,6,1 and 7 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 860617-64:
(8*8)+(7*6)+(6*0)+(5*6)+(4*1)+(3*7)+(2*6)+(1*4)=177
177 % 10 = 7
So 860617-64-7 is a valid CAS Registry Number.

860617-64-7Relevant articles and documents

SAR studies of 6-aryl-1,3-dihydrobenzimidazol-2-ones as progesterone receptor antagonists

Terefenko, Eugene A.,Kern, Jeffrey,Fensome, Andrew,Wrobel, Jay,Zhu, Yuan,Cohen, Jeffrey,Winneker, Richard,Zhang, Zhiming,Zhang, Puwen

, p. 3600 - 3603 (2005)

We have previously reported that the aryl substituted benzimidazolones, benzoxazinones, and oxindoles (e.g., 1-3) are progesterone receptor (PR) antagonists and have recently disclosed that the nature of 5- and 6-aryl moieties played a critical role in PR functional activity in the oxindole and benzoxazinone templates. For example, replacing the phenyl group of PR antagonists 2 and 3 with a 5′-cyanopyrrol-2′-yl moiety switched their functional activity to PR agonist activity (2a and 3a). These findings prompted us to examine if there is a similar effect of the 6-aryl moieties on the PR functional activity for the benzimidazolone template. Numerous analogs, such as 5, showed potent PR antagonist activity with about a 10-fold increase in potency as compared to those reported earlier in the same series. More interestingly, pyrrole-containing benzimidazolones 24-27 remained as PR antagonists in contrast to the PR agonist activity switch for oxindole and benzoxazinone scaffolds when a 5′-cyanopyrrol-2′-yl group was installed as a pendant aryl group.

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