860638-06-8Relevant academic research and scientific papers
Synthesis and Cu1+ assisted radiosynthesis of 2-radioiodo phloretinic acid, a potential glut tracer
Mertens, J.,Boumon, R.,Steegmans, P.
, p. S951 - S953 (2007/10/03)
2-Bromo-phloretinic acid (2-Br-PLA): 2-bromo-4-(3-oxo-3(2,4,6-trihydroxyphenyl)propyl)benzoic acid, the precursor molecule for the radiosynthesis of 2-radioiodo-phloretinic acid (2-*I-PLA): 2-radioiodo-4-(3-oxo-3(2,4,6-trihydroxyphenyl)propyl)benzoic acid, was prepared by a twelve step synthesis starting from hydrocinnamic acid. The radiosynthesis was carried out by applying the Cu(I)-assisted nucleophilic non-isotopic exchange reaction in acidic reducing medium.
