86071-01-4

Basic information

• Product Name: 7-(3-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}-2-hydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
• Synonyms: 7-(3-(4-(p-Fluorobenzoyl)piperidino)-2-hydroxypropyl)theophyllin
• CAS NO: 86071-01-4
• Molecular Formula: C₂₂H₂₆FN₅O₄
• Molecular Weight: 443.4713
• Mol File: 86071-01-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 685.9°C at 760 mmHg
• Flash Point: 368.6°C
• Density: 1.42g/cm³
• Vapor Pressure: 9.31E-20mmHg at 25°C
• Refractive Index: 1.666
• CAS DataBase Reference: 7-(3-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}-2-hydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(3-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}-2-hydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione(86071-01-4)
• EPA Substance Registry System: 7-(3-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}-2-hydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione(86071-01-4)

Safety Data

• Hazardous Substances Data: 86071-01-4(Hazardous Substances Data)

Upstream product

• 56346-57-7 (4-fluorophenyl)-piperidin-4-ylmethanone 
• 3880-32-8 7-(3-Chlor-2-hydroxy-propyl)-theophyllin 

Relevant articles and documents

New biologically active theophylline derivatives. Synthesis and pharmacologic properties of flufylline and fluprofylline

Within the course of the research project for finding new cardiovascular drugs we have synthetized since 1976 piperazine- and piperidine derivatives of theophylline. The screening shows for the substances Sgd 19578 (flufylline) and Sgd 14480 (fluprofylline) a long-lasting blood pressure lowering activity as well as a remarkable serotonin- and histamine antagonism and broncholytic activity. On the basis of these results these compounds were selected for further investigation.