860764-88-1Relevant articles and documents
Cu(i)-catalyzed tandem benzyldiazoester coupling with terminal alkyne-allene formation-Michael reaction: Application to the syntheses of oxa and azacycles
Kumaraswamy, Gullapalli,Jayaprakash, Neerasa,Balakishan, Guniganti
, p. 7913 - 7920 (2011/12/04)
A simple and practical procedure for the synthesis of aza- and oxacycles, which possess an array of stereogenic functionalities, is described. This protocol relies on tandem Cu-catalyzed coupling of suitably functionalized terminal alkyne with diazoester followed by isomerization and subsequent aza or oxa-Michael reaction, thus generating the required scaffold with high diastereoselectivity.
