860791-86-2Relevant academic research and scientific papers
Pyrrolo[1,5]benzoxa(thia)zepines as a new class of potent apoptotic agents. Biological studies and identification of an intracellular location of their drug target
Mc Gee, Margaret M.,Gemma, Sandra,Butini, Stefania,Ramunno, Anna,Zisterer, Daniela M.,Fattorusso, Caterina,Catalanotti, Bruno,Kukreja, Gagan,Fiorini, Isabella,Pisano, Claudio,Cucco, Carla,Novellino, Ettore,Nacci, Vito,Williams, D. Clive,Campiani, Giuseppe
, p. 4367 - 4377 (2007/10/03)
We have recently developed five novel pyrrolo-1,5-benzoxazepines as proapoptotic agents. Their JNK-dependent induction of apoptosis in tumor cells suggested their potential as novel anticancer agents. The core structure of the apoptotic agent 6 was invest
