860798-07-8

Upstream product

• 56341-37-8 6-chloro-2-oxindole 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 860797-94-0 (1''R,2''S,2'R,3'R,3S,4'R)-6-chloro-4'-(4-chlorophenyl)-1'-(2-hydroxy-1,2-diphenylethyl)-2'-isobutyl-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide 

Relevant academic research and scientific papers

Structure-based design of potent non-peptide MDM2 inhibitors

A successful structure-based design of a class of non-peptide small-molecule MDM2 inhibitors targeting the p53-MDM2 protein-protein interaction is reported. The most potent compound 1d binds to MDM2 protein with a Ki value of 86 nM and is 18 ti

SPIROINDOLINONE DERIVATIVES

The present invention relates to spiroindolinone derivatives of the formula and their enantiomers and pharmaceutically acceptable salts and esters thereof wherein R1, R2, R3, R4, R5, R6, R7 and R8, are as herein described.