86088-36-0

Upstream product

• 93-59-4 Perbenzoic acid 
• 1075-74-7 5-phenylpent-1-ene 
• 1119-51-3 bromopentene 
• 591-51-5 phenyllithium 

Downstream Products

• 2235-83-8 5-phenyl-2-pentanone 
• 858858-47-6 1-dimethylamino-5-phenyl-pentan-2-ol 
• 66377-63-7 (1,2,3,4-tetrahydronaphthalen-4-yl)methanol 
• 36884-28-3 5-phenyl-1-pentanal 
• 153558-53-3 5-phenyl-1,2-pentanediol 
• 220243-58-3 1-[benzyl(2-hydroxy-5-phenylpentyl)amino]-5-phenyl-2-pentanol 
• 399016-61-6 1-phenyl-trideca-1,6-diyn-4-ol 
• 399016-63-8 1-phenyl-7-trimethylsilanyl-hepta-1,6-diyn-4-ol 
• 422507-16-2 5-phenyl-1-phenylsulfanyl-pentan-2-ol 
• 791-28-6 Triphenylphosphine oxide 
• 116174-23-3 α-(3-phenylpropyl)-3-pyridineethanol 

Relevant academic research and scientific papers

Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin-MLL interaction

The natural product-like compound 1 was identified as a direct inhibitor of the menin-MLL interaction by in silico screening. Structure-based optimization furnished analogue 1a, which showed significantly higher potency than both the lead structure 1 and the reference compound MI-2.

Highly stereoselective Friedel-Crafts alkylations of unactivated benzenes by episulfonium ion cyclizations

Intermolecular additions of highly enantiomerically enriched episulfonium ions onto activated benzene rings are known to accomplish chiral Friedel-Crafts alkylations. Unactivated benzenes are either unreactive or can give low stereoselectivities. Intramol

Collagen cross-links: Synthesis of pyridinoline, deoxypyridinoline and their analogues

An efficient chiral synthesis of (S,S)-(-)-3g, a key intermediate for the preparation of collagen cross-links pyridinoline (Pyd, 1) and deoxypyridinoline (Dpd, 2) was achieved from (4S)-5(tert-butoxy)-4-[(tert- butoxycarbonyl)amino]-5-oxopentanoic acid (21b). Quaternization of (S,S)-(- )-3g with iodide (2S, 5R)-(+)-4a followed by hydrolysiS provided a first chiral synthesis of natural (+)-Pyd (1). 1-(2S)-(+)-Pyd (1) was also synthesized from (S,S)-(-)-3g and iodide (2S, 5S)-(+)-4a. Similarly, quaternization of (S,S)-(-)-3g with iodide (2S)-(-)-4b, which was prepared from (2S)-(-)-6-amino-2[(tert-butoxycarbonyl)amino]hexanoic acid (31) in three steps, followed by hydrolysis afforded natural (+)-Dpd (2) in 5.3% overall yield. Also, the synthesis of racemic Dpd [(±)-2] and a variety of its analogues is presented.

Alpha-(phenylalkyl) pyridinealkanol derivatives

This invention relates to novel α-(phenylalkyl) pyridinealkanol derivatives useful in the treatment of diseases or disorders mediated by platelet-activating factor. This invention further relates to pharmaceutical compositions of such α-(phenylalkyl)pyridinealkanol derivatives.

Certain 1H-imidazol-1-yl-1-lower-alkanoic acid derivatives having anti-thrombotic activity

Compounds of the general formula STR1 and pharmaceutically acceptable salts thereof have antithrombotic activity. Het represents 1-[1H-imidazolyl], 1-N-morpholinyl or pyridyl. A representative compound is 6-[2-(1H-Imidazol-1-yl)-1-yl-1-[[(4-methoxyphenyl)methoxy]methyl]ethoxy]hexanoic acid.