86088-36-0

Basic information

• Product Name: 2-(3-phenyl-propyl)-oxirane
• Synonyms: 2-(3-phenyl-propyl)-oxirane
• CAS NO: 86088-36-0
• Molecular Weight: 162.232
• Mol File: 86088-36-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(3-phenyl-propyl)-oxirane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-phenyl-propyl)-oxirane(86088-36-0)
• EPA Substance Registry System: 2-(3-phenyl-propyl)-oxirane(86088-36-0)

Safety Data

• Hazardous Substances Data: 86088-36-0(Hazardous Substances Data)

Upstream product

• 93-59-4 Perbenzoic acid 
• 1075-74-7 5-phenylpent-1-ene 
• 1119-51-3 bromopentene 
• 591-51-5 phenyllithium 

Downstream Products

• 399016-61-6 1-phenyl-trideca-1,6-diyn-4-ol 
• 399016-63-8 1-phenyl-7-trimethylsilanyl-hepta-1,6-diyn-4-ol 
• 116174-23-3 α-(3-phenylpropyl)-3-pyridineethanol 
• 791-28-6 Triphenylphosphine oxide 
• 422507-16-2 5-phenyl-1-phenylsulfanyl-pentan-2-ol 
• 2235-83-8 5-phenyl-2-pentanone 
• 220243-58-3 1-[benzyl(2-hydroxy-5-phenylpentyl)amino]-5-phenyl-2-pentanol 
• 66377-63-7 (1,2,3,4-tetrahydronaphthalen-4-yl)methanol 
• 36884-28-3 5-phenyl-1-pentanal 
• 153558-53-3 5-phenyl-1,2-pentanediol 
• 858858-47-6 1-dimethylamino-5-phenyl-pentan-2-ol 

Relevant articles and documents

Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin-MLL interaction

The natural product-like compound 1 was identified as a direct inhibitor of the menin-MLL interaction by in silico screening. Structure-based optimization furnished analogue 1a, which showed significantly higher potency than both the lead structure 1 and the reference compound MI-2.

Collagen cross-links: Synthesis of pyridinoline, deoxypyridinoline and their analogues

An efficient chiral synthesis of (S,S)-(-)-3g, a key intermediate for the preparation of collagen cross-links pyridinoline (Pyd, 1) and deoxypyridinoline (Dpd, 2) was achieved from (4S)-5(tert-butoxy)-4-[(tert- butoxycarbonyl)amino]-5-oxopentanoic acid (21b). Quaternization of (S,S)-(- )-3g with iodide (2S, 5R)-(+)-4a followed by hydrolysiS provided a first chiral synthesis of natural (+)-Pyd (1). 1-(2S)-(+)-Pyd (1) was also synthesized from (S,S)-(-)-3g and iodide (2S, 5S)-(+)-4a. Similarly, quaternization of (S,S)-(-)-3g with iodide (2S)-(-)-4b, which was prepared from (2S)-(-)-6-amino-2[(tert-butoxycarbonyl)amino]hexanoic acid (31) in three steps, followed by hydrolysis afforded natural (+)-Dpd (2) in 5.3% overall yield. Also, the synthesis of racemic Dpd [(±)-2] and a variety of its analogues is presented.

Certain 1H-imidazol-1-yl-1-lower-alkanoic acid derivatives having anti-thrombotic activity

Compounds of the general formula STR1 and pharmaceutically acceptable salts thereof have antithrombotic activity. Het represents 1-[1H-imidazolyl], 1-N-morpholinyl or pyridyl. A representative compound is 6-[2-(1H-Imidazol-1-yl)-1-yl-1-[[(4-methoxyphenyl)methoxy]methyl]ethoxy]hexanoic acid.