86088-40-6

Basic information

• Product Name: 1-methyl-1,2,3,4-tetrahydronaphthalen-2-ol
• CAS NO: 86088-40-6
• Molecular Formula: C₁₁H₁₄O
• Molecular Weight: 162.2283
• Mol File: 86088-40-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 276.5°C at 760 mmHg
• Flash Point: 103.8°C
• Density: 1.058g/cm³
• Vapor Pressure: 0.0023mmHg at 25°C
• Refractive Index: 1.557
• CAS DataBase Reference: 1-methyl-1,2,3,4-tetrahydronaphthalen-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-1,2,3,4-tetrahydronaphthalen-2-ol(86088-40-6)
• EPA Substance Registry System: 1-methyl-1,2,3,4-tetrahydronaphthalen-2-ol(86088-40-6)

Safety Data

• Hazardous Substances Data: 86088-40-6(Hazardous Substances Data)

Usage

Classification

Secondary alcohol
1-methyl-1,2,3,4-tetrahydronaphthalen-2-ol is classified as a secondary alcohol because the hydroxyl (OH) group is attached to a carbon atom which is bonded to two other carbon atoms.

Physical properties

Colorless liquid, pleasant odor
The compound is a colorless liquid with a pleasant smell, making it suitable for use in perfumes and flavoring agents.

Industrial applications

Perfumes, flavoring agents, pharmaceuticals, and solvents
1-methyl-1,2,3,4-tetrahydronaphthalen-2-ol is used in the manufacture of perfumes, as a flavoring agent in the food industry, in the production of pharmaceuticals, and as a solvent in various chemical processes.

Medicinal properties

Anti-inflammatory and analgesic effects
The compound has been studied for its potential medicinal properties, including its ability to act as an anti-inflammatory and analgesic agent, which may help in reducing inflammation and pain.

Upstream product

• 5419-02-3 1-dimethylaminomethyl-naphthalen-2-ol 
• 4024-14-0 1-methyl-2-tetralone 
• 917-64-6 methyl magnesium iodide 
• 2461-34-9 1a,2,3,7b-tetrahydronaphtho[1,2-b]oxirene 
• 1745-16-0 5-phenylpent-2-ene 
• 344753-07-7 2,3-epoxy-5-phenylpentane 
• 1096-84-0 bis(2-hydroxy-1-naphthyl)methane 
• 1076-26-2 1-methyl-2-naphthol 
• 5342-95-0 1-piperidin-1-ylmethyl-naphthalen-2-ol 

Downstream Products

• 87751-20-0 Acetic acid 1-[2-(3-oxo-propyl)-phenyl]-ethyl ester 

Relevant articles and documents

Application of robust ketoreductase from Hansenula polymorpha for the reduction of carbonyl compounds

Enzyme-catalysed asymmetric reduction of ketones is an attractive tool for the production of chiral building blocks or precursors for the synthesis of bioactive compounds. Expression of robust ketoreductase (KRED) from Hansenula polymorpha was upscaled and applied for the asymmetric reduction of 31 prochiral carbonyl compounds (aliphatic and aromatic ketones, diketones and β-keto esters) to the corresponding optically pure hydroxy compounds. Biotransformations were performed with the purified recombinant KRED together with NADP+ recycling glucose dehydrogenase (GDH, Bacillus megaterium), both overexpressed in Escherichia coli BL21(DE3). Maximum activity of KRED for biotransformation of ethyl-2-methylacetoacetate achieved by the high cell density cultivation was 2499.7 ± 234 U g–1DCW and 8.47 ± 0.40 U·mg–1E, respectively. The KRED from Hansenula polymorpha is a very versatile enzyme with broad substrate specificity and high activity towards carbonyl substrates with various structural features. Among the 36 carbonyl substrates screened in this study, the KRED showed activity with 31, with high enantioselectivity in most cases. With several ketones, the Hansenula polymorpha KRED catalysed preferentially the formation of the (R)-secondary alcohols, which is highly valued.

Friedel-crafts cyclialkylations of some epoxides. 2. Stereospecificity, substituent, product, and kinetic studies

The relative facility of the cyclialkylation of several arylalkyl epoxides was investigated. Stereochemical studies on the cyclialkylation of cis- and trans-2,3-epoxy-5-phenylpentane establish that the stereospecificity of ring formation is as high as 97%

A Novel Route for the Synthesis of 3,4-Dihydro-1H-2-benzopyrans and 1,3,4,5-Tetrahydro-2-benzoxepins

-