860994-91-8Relevant academic research and scientific papers
Design and development of bioinspired guanine-based organic catalyst for asymmetric catalysis
Suez, Gal,Bloch, Victoria,Nisnevich, Gennady,Gandelman, Mark
, p. 2118 - 2122 (2012/06/01)
Design, preparation, and studies of a family of new organic catalysts are presented. The design of the catalysts is inspired by the ability of DNA nucleobases to develop precise and explicit hydrogen bonds. We have shown that this phenomenon can be used to create a useful organic catalyst that demonstrates a recognition pattern similar to those of common organic substrates. A selected bifunctional catalyst based on a guanine structure has been shown to catalyze the conjugate addition of 1,3-dicarbonyl compounds to various nitroalkenes, providing the products in good yields and enantioselectivities.
A simple primary-tertiary diamine-Bronsted acid catalyst for asymmetric direct aldol reactions of linear aliphatic ketones
Luo, Sanzhong,Xu, Hui,Li, Jiuyuan,Zhang, Long,Cheng, Jin-Pei
, p. 3074 - 3075 (2007/10/03)
Compared with the well-explored enamine catalysis with secondary amines, the development of efficient enamine-based primary amine catalysts has remained as an elusive goal until recently. We present herein that a simple chiral primary-tertiary diamine 1d
Thiourea-catalyzed enantioselective cyanosilylation of ketones
Fuerst, Douglas E.,Jacobsen, Eric N.
, p. 8964 - 8965 (2007/10/03)
The new chiral amino thiourea catalyst 3d promotes the highly enantioselective cyanosilylation of a wide variety of ketones. The hindered tertiary amine substituent plays a crucial role with regard to both stereoinduction and reactivity, suggesting a coop
