861064-92-8Relevant academic research and scientific papers
Novel, potent, selective, and brain penetrant phosphodiesterase 10A inhibitors
Geneste, Hervé,Drescher, Karla,Jakob, Clarissa,Laplanche, Lo?c,Ochse, Michael,Torrent, Maricel
, p. 406 - 412 (2019/01/04)
Herein we report the discovery of a novel series of phosphodiesterase 10A inhibitors. Optimization of a HTS hit (17) resulted in potent, selective, and brain penetrant 23 and 26; both exhibited much lower clearance in vivo and decreased volume of distribu
INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A
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Page/Page column 63, (2014/03/22)
The present invention relates to compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof, where in formula I the variables R1, R2, R3, R4 and R5/
