861090-79-1Relevant academic research and scientific papers
Naphthyl-substituted sulfonamides
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Page/Page column 21, (2009/04/23)
The present application relates to naphtyl substituted sulfonamides according to general formula (I) with 5-HT6 receptor affinity, a medicament comprising a said compound, and the use of one of said compounds for the manufacture of a medicament.
SULFONAMIDE ENDOTHELIN ANTAGONISTS
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, (2008/06/13)
Compounds of the formula STR1 inhibit endothelin, wherein: one of X and Y is N and the other is O; R is naphthyl or naphthyl substituted with R. sup.1, R 2 and R 3 ;R 1, R 2 and R 3 are each independently hydrogen; alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, or aralkyl, any of which may be substituted with Z 1, Z 2 and Z 3 ; halo; hydroxyl; cyano; nitro;--C(O)H;--C(O)R 6 ; CO 2 H;--CO 2 R 6 ;--SH;--S(O) n R 6 ;--S(O) m--OH;--S(O). sub.m--OR 6 ;--O--S(O) m--R 6 ;--O--S(O) m OH;--O--S(O) m--OR. sup.6 ;--Z 4--NR 7 R 8 ; or--Z 4--N(R. sup.11)--Z 5--NR 9 R 10 ;R 4 and R 5 are each independently hydrogen; alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, or aralkyl, any of which may be substituted with Z 1, Z 2 and Z 3 ; halo; hydroxyl; cyano; nitro;--C(O)H;--C(O)R 6 ;--CO 2 H;--CO 2 R 6 ;--SH,--S(O) n R. sup.6 ;--S(O) m--OH;--S(O) m--OR 6 ;--O--S(O) m--R. sup.6 ;--O--S(O) m OH;--O--S(O) m--OR. sup.6 ;--Z 4--NR. sup.7 R 8 ;--Z 4--N(R. sup.11)--Z 5--NR. sup.9 R 10 ; or R 4 and R 5 together are alkylene or alkenylene (either of which may be substituted with Z 1, Z 2 and Z 3), completing a 4-to 8-membered saturated, unsaturated or aromatic ring together with the carbon atoms to which they are attached.
