861106-15-2

Upstream product

• 1711-07-5 3-fluorobenzoyl chloride 
• 77326-36-4 2-amino-6-fluorobenzonitrile 
• 1153761-87-5 N-(2-cyano-3-fluorophenyl)-3-fluorobenzamide 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 861106-27-6 4-[2-aminomethyl-3-(3-fluoro-benzylamino)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 1211312-10-5 4-[1-(3-fluorobenzyl)-2-oxo-1,2,3,4-tetrahydroquinazolin-5-yl]piperazine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Improved synthesis of RO4858542, a 5-HT6 receptor antagonist

An improved synthesis of a 5-HT6 antagonist is described. A problematic amide reduction step was avoided by a reductive amination. Overall, 2.9 kg was produced over 6 steps with an overall yield of 56%.

1-BENZYL-5-PIPERAZIN-1-YL-3,4 DIHYDRO-1H-QUINAZOLIN-2-ONE DERIVATIVES AND THE RESPECTIVE 1H-BENZO(1,2,6)THIADIAZINE-2,2-DIOXIDE AND 1,4-DIHYDRO-BENZO(D) (1,3)OXAZIN-2-ONE DERIVATIVES AS MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR (5-HT) FOR THE TREATME

The invention relates to substituted quinazolinone compunds of formula (I) or a pharmaceutically acceptable salt thereof, wherein Y is C or S; m is 1 when Y is C and m is 2 when Y is S; n is 1 or 2; p is from 0 to 3; q is from 1 to 3; Z is -(CRa/sup