861137-52-2

Basic information

• Product Name: (E)-1-(3-bromo-2-hydroxyl-4,6-dimethoxyphenyl)-3-(4-chlorophenyl)prop-2-en-1-one
• Synonyms: (E)-1-(3-bromo-2-hydroxyl-4,6-dimethoxyphenyl)-3-(4-chlorophenyl)prop-2-en-1-one
• CAS NO: 861137-52-2
• Molecular Weight: 397.653
• Mol File: 861137-52-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-1-(3-bromo-2-hydroxyl-4,6-dimethoxyphenyl)-3-(4-chlorophenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(3-bromo-2-hydroxyl-4,6-dimethoxyphenyl)-3-(4-chlorophenyl)prop-2-en-1-one(861137-52-2)
• EPA Substance Registry System: (E)-1-(3-bromo-2-hydroxyl-4,6-dimethoxyphenyl)-3-(4-chlorophenyl)prop-2-en-1-one(861137-52-2)

Safety Data

• Hazardous Substances Data: 861137-52-2(Hazardous Substances Data)

Upstream product

• 18064-89-6 1-(3-bromo-2-hydroxyl-4,6-dimethoxyphenyl)ethanone 
• 104-88-1 4-chlorobenzaldehyde 
• 621-23-8 1,2,3-trimethoxybenzene 
• 155673-98-6 (E)-3-(4-chlorophenyl)-1-(2'-hydroxy-4',6'-dimethoxyphenyl)prop-2-en-1-one 

Relevant articles and documents

Synthesis and biological evaluation of novel series of chalcone derivatives as inhibitors of cyclooxygenase and LPS-induced TNF-α with potent antioxidant properties

Novel series of chalcones were synthesized and were evaluated as possible anti-inflammatory agents targeting the cyclooxygenase-1 and 2 (COX-1 and 2), β-glucuronidase, trypsin, and TNF-α. Amongst the tested chalcones the compound 4k was found to be most effective inhibitor of TNF-α exhibiting 85% inhibition activity (IC50 = 0.1 μM). The compounds 4a, 4f, 4l, and 4m were found to inhibit the COX-1 activity in as a range of 79.95-68.47% and COX-2 inhibition ranging 84.45-74.77%. The compounds 4l (81.71%) and 4f (72.10%) were found to be excellent inhibitors of trypsin and β-glucuronidase, respectively. Springer Science+Business Media, LLC 2011.