861145-33-7Relevant academic research and scientific papers
Formal synthesis of (±)-clausenamide by nhc-catalyzed γ-lactam formation
He, Ming,Rommel, Michael,Bode, Jeffrey W.
, p. 1689 - 1696 (2013/08/23)
(±)-Clausenamide is a biologically active γ-lactam isolated as a racemic mixture from Clausena lansium. Reported medicinal properties include hepatoprotective effects as well as neuroprotective and nootropic activity. In order to improve synthetic access
ENANTIOSELECTVE REACTIONS CATALYZED BY CHIRAL TRIAZOLIUM SALTS
-
Page/Page column 49-50, (2010/11/28)
This invention provides a convenient method for converting imines and other electrophiles into heterocyclic ring systems. The process does not require the use of metallic reagents, and is catalyzed by an organic heterocyclic carbene catalyst. Accordingly,
Highly enantioselective azadiene diels-alder reactions catalyzed by chiral N-heterocyclic carbenes
He, Ming,Struble, Justin R.,Bode, Jeffrey W.
, p. 8418 - 8420 (2007/10/03)
Highly enantioselective, N-heterocyclic carbene (NHC)-catalyzed aza-Diels-Alder reactions are described. A novel chiral triazolium salt based on the cis-1,2-aminoindanol platform serves as an efficient precatalyst for the NHC-catalyzed redox generation of
Catalytic synthesis of γ-lactams via direct annulations of enals and N-sulfonylimines
He, Ming,Bode, Jeffrey W.
, p. 3131 - 3134 (2007/10/03)
(Chemical Equation Presented) Cinnamaldehydes and N-sulfonylimines undergo direct annulations to cis-disubstituted γ-lactams via the intermediacy of catalytically generated homoenolates. Critical to the success of this process was overcoming inhibition of the N-heterocyclic carbene catalyst by the electrophilic imines. The overall process proceeds with good yields and diastereoselectivites and requires no stoichiometric reagents or additives.
