861199-86-2Relevant articles and documents
Synthesis, X-ray Structure Determination, and Comprehensive Photochemical Characterization of (Trifluoromethyl)diazirine-Containing TRPML1 Ligands
Schwickert, Kevin,Andrzejewski, Micha?,Grabowsky, Simon,Schirmeister, Tanja
, p. 6169 - 6183 (2021)
Potential (trifluoromethyl)diazirine-based TRPML1 ion channel ligands were designed and synthesized, and their structures were determined by single-crystal X-ray diffraction analysis. Photoactivation studies via 19F NMR spectroscopy and HPLC-MS analysis revealed distinct kinetical characteristics in selected solvents and favorable photochemical properties in an aqueous buffer. These photoactivatable TRPML activators represent useful and valuable tools for TRPML photoaffinity labeling combined with mass spectrometry.
ANTI-AMYLOID COMPOUNDS AND METHODS
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Page/Page column 72, (2012/09/21)
Anti-amyloid compounds are provided along with methods of use thereof.
Discovery of novel FMS kinase inhibitors as anti-inflammatory agents
Illig, Carl R.,Chen, Jinsheng,Wall, Mark J.,Wilson, Kenneth J.,Ballentine, Shelley K.,Rudolph, M. Jonathan,DesJarlais, Renee L.,Chen, Yanmin,Schubert, Carsten,Petrounia, Ioanna,Crysler, Carl S.,Molloy, Christopher J.,Chaikin, Margery A.,Manthey, Carl L.,Player, Mark R.,Tomczuk, Bruce E.,Meegalla, Sanath K.
, p. 1642 - 1648 (2008/12/22)
The optimization of the arylamide lead 2 resulted in identification of a highly potent series of 2,4-disubstituted arylamides. Compound 8 (FMS kinase IC50 = 0.0008 μM) served as a proof-of-concept candidate in a collagen-induced model of arthri
