861222-41-5

Upstream product

• 861222-40-4 ethyl (2E,4S)-5-(tert-butyldiphenylsilanyloxy)-4-(methoxymethyloxy)-2-pentenoate 
• 108-86-1 bromobenzene 
• 10446-09-0 (S)-ethyl trans-4,5-dihydroxylpent-2-enoate 
• 64520-58-7 ethyl (E)-3-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)acrylate 
• 885051-17-2 ethyl (2E,4S)-5-(tert-butyldiphenylsilanyloxy)-4-hydroxy-2-pentenoate 

Downstream Products

• 861222-42-6 (4R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)-4-benzyldihydrofuran-2(3H)-one 
• 156848-00-9 (4S,5R)-5-(hydroxymethyl)-4-phenyldihydrofuran-2(3H)-one 

Relevant academic research and scientific papers

Selectivity guidelines and a reductive elimination-based model for predicting the stereochemical course of conjugate addition reactions of organocuprates to γ-alkoxy-α,β-enoates

Current models used to predict the stereochemical outcome of organocopper conjugate addition processes focus on the nucleophilic addition step as stereochemistry-determining. Recent kinetic, NMR, kinetic isotope effect, and theoretical density functional

Highly anti-selective conjugate addition of arylcuprates to a γ-alkoxy-α,β-enoate. A new method to address stereochemical challenges presented by Amaryllidaceae alkaloids

Various substituted arylcuprates undergo stereocontrolled additions to a d-mannitol-derived γ-alkoxy-α,β-enoate with exclusive anti-selectivity. The method is well suited for the preparation of a broad range of biologically active Amaryllidaceae alkaloids