861328-28-1

Basic information

• Product Name: 1-(3-ethoxycarbonyloxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline
• CAS NO: 861328-28-1
• Molecular Weight: 399.444
• Mol File: 861328-28-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3-ethoxycarbonyloxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-ethoxycarbonyloxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline(861328-28-1)
• EPA Substance Registry System: 1-(3-ethoxycarbonyloxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline(861328-28-1)

Safety Data

• Hazardous Substances Data: 861328-28-1(Hazardous Substances Data)

Upstream product

• 861323-48-0 (3-ethoxycarbonyloxy-4-methoxy-phenyl)-acetic acid 
• 861364-71-8 (3-ethoxycarbonyloxy-4-methoxy-phenyl)-acetic acid-(3,4-dimethoxy-phenethylamide) 
• 1131-94-8 homoisovanillic acid 

Relevant articles and documents

Biotransformation of phenolic tetrahydroprotoberberines in plant cell cultures followed by LC-NMR, LC-MS, and LC-CD

A metabolic pathway of 2,3,10,11-oxygenated tetrahydroprotoberberines having the OH group on ring D was demonstrated. Metabolism of 13C- or D2-labeled precursors was studied in cell cultures of Macleaya, Corydalis, and Nandina species. The structures of alkaloid metabolites obtained from feeding experiments were determined by application of combined LC-NMR, LC-MS/MS, and LC-CD techniques. (S)-Tetrahydropseudoprotoberberine (5) was stereospecifically O-methylated to the 5-isomer (12) in cell cultures of three plant species. This 5-isomer was further N-methylated to the (5)-α-N-methyl salt (15), which was oxidized to produce the pseudoprotopine-type alkaloid (10) in cell cultures of Macleaya and Corydalis species. These transformations were the same as those of 2,3,9,10-oxygenated protoberberines. The tetrahydropseudoprotoberberines (5, 6, and 12) were dehydrogenated to pseudoprotoberberines (13, 16, and 14), respectively. Both the R- and 5-enantiomers of 5 were dehydrogenated in Macleaya cordata different from the case of 2,3,9,10-oxygenated protoberberines. Precursor 7, with OH groups at C-10 and C-11was O-methylated at C-10 in M. cordata and C. ochotensis var. raddeana, which was distinct from O-methylation in N. domestica, in which 7 was O-methylated at both C-11 and C-10. Stereoselective O-demethylation [(S)-S to (5)-18] occurred in N. domestica.