86133-53-1

Upstream product

• 14213-00-4 2,4,6-trimethylaniline azide 
• 603-35-0 triphenylphosphine 
• 88-05-1 2,4,6-trimethylaniline 

Downstream Products

• 791-28-6 Triphenylphosphine oxide 
• 95970-03-9 (2,2,2-Trichloro-1,1-difluoro-ethyl)-(2,4,6-trimethyl-phenyl)-carbodiimide 
• 125535-90-2 N-mesityl-N'-(phenyldifluoromethyl)carbodiimide 
• 126088-16-2 N-1-(butoxythiocarbonylthio)-2,2,2-trichloroethyl-N'-2,4,6-trimethylphenylcarbodiimide 
• 865073-52-5 N-phenyl-N'-(2,4,6-trimethylphenyl)-1H-benzotriazole-1-carboximidamide 
• 126088-15-1 N-1-(ethoxythiocarbonylthio)-1-phenyl-2,2,2-trifluoroethyl-N'-2,4,6-trimethylphenylcarbodiimide 

Relevant academic research and scientific papers

A Chromium(II) Tetracarbene Complex Allows Unprecedented Oxidative Group Transfer

Multiple distinct oxidative group transfer reactions to low valent chromium were examined. Six new chromium complexes were prepared from a highly electronically unsaturated Cr(II) square planar complex that was supported by a macrocyclic tetracarbene ligand. This complex's reactivity with Me3NO and disparate azides was investigated. The reaction with Me3NO generated a highly stable Cr(IV)-oxo complex. Less bulky organic azides such as p-tolyl and n-octyl azides gave rise to metallotetrazenes, while more sterically demanding mesityl and adamantyl azides generated Cr(IV)-imido complexes. The reaction of the square planar Cr(II) complex with TMS-azide yielded the first linearly bridging nitrido chromium species. Reductive group transfer was explored for a Cr(IV)-imido complex, and organic products, such as aziridines, were formed after addition. Cr(IV) imidos and oxos are quite rare, while tetrazenes and bridging nitridos are virtually unknown. This is the most detailed study on oxidative group transfer reactions using chromium based complexes on a single auxiliary ligand to date.

Evidence of two-state reactivity in alkane hydroxylation by Lewis-acid bound copper-nitrene complexes

The behavior of the Lewis-acid adducts of two copper-nitrene [Cu(NR)] + complexes in nitrene-transfer and H-atom abstraction reactions have been demonstrated to depend on the nature of the nitrene substituents. Two-state reactivity, in which a singlet ground state and a nearby triplet excited-state both contribute, provides a useful model for interpreting reactivity trends of the two compounds.

The preparation of 1,2,3-trisubstituted guanidines

An operationally straightforward and efficient benzotriazole-based method for the guanylation of diverse amines by use of the new reagent classes (bis-benzotriazol-1-yl-methylene)amines 13a-13f and benzotriazole-1- carboxamidines 17a-17i is described. The preparation is described for a variety of both acyclic and cyclic 1,2,3-trisubstituted guanidines in high yields.