861337-74-8 Usage
Description
2-Nitrophenethylamine Hydrochloride is an organic compound that serves as an essential intermediate in the synthesis of various pharmaceuticals and chemical compounds. It is characterized by the presence of a nitro group attached to a phenyl ring and an ethylamine group, which can be protonated to form the hydrochloride salt. 2-NITROPHENETHYLAMINE HYDROCHLORIDE plays a crucial role in the development of new therapeutic agents and chemical processes.
Uses
Used in Pharmaceutical Industry:
2-Nitrophenethylamine Hydrochloride is used as a key intermediate in the preparation of diaminopyrimidines, which are potent MTH-1 inhibitors. These inhibitors have significant potential in the treatment of cancer, as they can effectively target and disrupt the activity of enzymes involved in DNA repair mechanisms, leading to the suppression of tumor growth and increased sensitivity to chemotherapy.
Used in Chemical Synthesis:
2-Nitrophenethylamine Hydrochloride is also utilized in the synthesis of o-Nitrohydrocinnamic acid, a valuable chemical compound with various applications in the chemical and pharmaceutical industries. The synthesis of o-Nitrohydrocinnamic acid from 2-Nitrophenethylamine Hydrochloride involves a series of chemical reactions that can be further modified to produce a range of related compounds with diverse properties and uses.
Check Digit Verification of cas no
The CAS Registry Mumber 861337-74-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,1,3,3 and 7 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 861337-74:
(8*8)+(7*6)+(6*1)+(5*3)+(4*3)+(3*7)+(2*7)+(1*4)=178
178 % 10 = 8
So 861337-74-8 is a valid CAS Registry Number.
861337-74-8Relevant articles and documents
Catalytic Staudinger Reduction at Room Temperature
Lenstra, Danny C.,Wolf, Joris J.,Mecinovi?, Jasmin
, p. 6536 - 6545 (2019/05/24)
We report an efficient catalytic Staudinger reduction at room temperature that enables the preparation of a structurally diverse set of amines from azides in excellent yields. The reaction is based on the use of catalytic amounts of triphenylphosphine as a phosphine source and diphenyldisiloxane as a reducing agent. Our catalytic Staudinger reduction exhibits a high chemoselectivity, as exemplified by reduction of azides over other common functionalities, including nitriles, alkenes, alkynes, esters, and ketones.
COMPOUNDS, COMPOSITIONS AND METHODS
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Page/Page column 70-71; 36, (2010/11/24)
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
