861343-73-9

Usage

Uses

Used in Organic Synthesis:
BenzenaMine, 2-[(1-Methylethyl)thio]-, hydrochloride (1:1) is used as a reagent in the field of organic synthesis for its unique chemical properties, which can contribute to the formation of complex molecules and compounds.
Used in Pharmaceutical Development:
In the pharmaceutical industry, BenzenaMine, 2-[(1-Methylethyl)thio]-, hydrochloride (1:1) is used as an intermediate in the synthesis of various drugs, potentially due to its ability to form stable bonds with other molecules, facilitating the creation of new therapeutic agents.

Upstream product

• 70415-85-9 2-(isopropyl sulfanyl)nitrobenzene 
• 1493-27-2 ortho-nitrofluorobenzene 

Relevant academic research and scientific papers

Anti-cancer drug ceritinib intermediate 1-amino-2-(isopropyl sulfonyl)benzene synthetic method

The invention belongs to the technical field of medicine synthesis, and especially relates to a synthetic method of an anti-cancer drug ceritinib intermediate 1-amino-2-(isopropyl sulfonyl)benzene. The synthetic method comprises the following steps: employing o-fluoronitrobenzene, sodium hydride and isopropyl mercaptan to synthesize a 2-(isopropyl sulfide) nitrobenzene crude product, then directly reducing the crude product to iron powder, forming salt to obtain the 2-(isopropyl sulfide) aniline hydrochloride, and finally dropping hydrogen peroxide for oxidation in 2-(isopropyl sulfide) aniline hydrochloride for oxidation, forming salt, and dissociating to obtain a target product. The synthetic method has the advantages of simpleness, little sewage amount, low energy consumption, low production cost, and the product has the advantages of high purity, high yield, and easy industrial production, and is suitable for further popularization and application.