861369-05-3Relevant academic research and scientific papers
Preparation method of 3-halo-2,3-dihydro-4-quinolinone
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Paragraph 0028; 0035-0037, (2018/05/01)
The invention discloses a preparation method of 3-halo-2,3-dihydro-4-quinolinone. According to the preparation method, an o-propargyl alcohol-aniline derivative and N-halogenated succinimide are usedas raw materials, and a Meyer-Schuster rearrangement reaction and a halogenation reaction are carried out in series under the action of acid so as to realize one-pot synthesis of 3-halo-2,3-dihydro-4-quinolinone. The highest yield of the preparation method provided by the invention can reach 90%, and the preparation method has the advantages of simple operation, mild condition, high conversion rate, few byproducts and the like, and provides a brand-new synthesis method for construction of a 3-halo-2,3-dihydro-4-quinolinone compound.
