861374-56-3Relevant academic research and scientific papers
One-pot method for regioselective bromination and sequential carbon-carbon bond-forming reactions of allylic alcohol derivatives
Kutsumura, Noriki,Matsubara, Yusuke,Niwa, Kentaro,Ito, Ai,Saito, Takao
, p. 3337 - 3346 (2013/06/27)
An efficient one-pot method for the regioselective bromination of allylic alcohol derivatives (two-step reaction sequence) followed by Sonogashira, Negishi, or Suzuki-Miyaura coupling reactions in the same reaction vessel (three-step reaction sequence) ha
1,8-diazabicyclo[5.4.0]undec-7-ene-promoted regioselective elimination of vicinal dibromides having an adjacent O-and/or N-functional group
Kutsumura, Noriki,Iijima, Masatoshi,Toguchi, Shohei,Saito, Takao
supporting information; experimental part, p. 1231 - 1232 (2011/11/30)
We have investigated the DBU-promoted HBr-elimination of vicinal dibromides having an adjacent O- and/or N-functional group under mild basic conditions. The elimination of 1-oxygenfunctionalized 2,3-dibromopropanes was more regioselective than that of 1-n
Novel one-pot method for chemoselective bromination and sequential sonogashira coupling
Kutsumura, Noriki,Niwa, Kentaro,Saito, Takao
supporting information; experimental part, p. 3316 - 3319 (2010/10/19)
(Equation Presented). An efficient one-pot method for bromination- elimination of allyl alcohol derivatives and sequential Sonogashira coupling has been developed. A highlight of the method is chemoselective DBU-promoted elimination of vicinal dibromoalka
Efficient synthesis of propargylic ethers under the DBU conditions and its application to natural products synthesis
Yokoyama, Tadashi,Kutsumura, Noriki,Ohgiya, Tadaaki,Nishiyama, Shigeru
, p. 578 - 582 (2008/02/11)
Conversion of dibromides carrying O-functional groups at adjacent positions to the corresponding propargylic ethers was successfully carried out under the DBU conditions through 2-bromo-1-alkenes as intermediates. The optically active γ-lactone-class natural products, such as (-)-muricatacin (4) and (R,R)-sapinofuranone B (5) were synthesized using the propargylic ether intermediate produced by the elimination reaction mentioned above.
1,2-Dibromoalkanes into alkynes by elimination reaction under DBU conditions and their application to total synthesis of sapinofuranone B
Kutsumura, Noriki,Yokoyama, Tadashi,Ohgiya, Tadaaki,Nishiyama, Shigeru
, p. 4133 - 4136 (2007/10/03)
Treatment of 1,2-dibromoalkanes with DBU effected an elimination reaction, leading to the alkynes. Oxygen substitution at the C3 position plays a critical role to abstract protons by inductive effects. By the application of this protocol, a total synthesi
