861401-55-0Relevant academic research and scientific papers
Design and synthesis of novel ring-expanded arbekacin analogues
Minowa, Nobuto,Hiraiwa, Yukiko,Akiyama, Yoshihisa,Maebashi, Kazunori,Usui, Takayuki,Ikeda, Daishiro
, p. 1715 - 1721 (2007)
Novel homologated aminoglycosides having a seven-membered ring were designed and synthesized by treatment of 5-keto arbekacin with diazomethane in CH2Cl2-Et2O. The ring-expanded arbekacin analogue showed good antibacterial
NOVEL AMINOGLYCOSIDE ANTIBIOTIC EFFECTIVE AGAINST METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS (MRSA)
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Page/Page column 94, (2010/11/24)
Disclosed are compounds represented by general formula (I) or pharmacologically acceptable salts or solvates thereof having excellent antimicrobial activity against bacteria causative of severe infections such as pneumonia and septicemia, particularly against MRSA, and also antimicrobial agents comprising these compounds, and pharmaceutical compositions comprising these compounds as an active component.
