861405-68-7Relevant academic research and scientific papers
Efficient and selective Pt/C-catalyzed H-D exchange reaction of aromatic rings
Ito, Nobuhiro,Esaki, Hiroyoshi,Maesawa, Tsuneaki,Imamiya, Eikoh,Maegawa, Tomohiro,Sajiki, Hironao
experimental part, p. 278 - 286 (2009/03/12)
An effective and applicable deuteration method for aromatic rings using Pt/C-D2O-H2 system was established. Especially, phenol was fully deuterated even at room temperature, and other electron-rich aromatic nuclei were efficiently deuterated under mild conditions. The scope and limitations of the presence method and its application to the synthesis of deuterium-labeled biologically active compounds and deuterium-labeled building blocks for practical multi-gram scale syntheses are reported. 2008 The Chemical Society of Japan.
H-D exchange reaction taking advantage of the synergistic effect of heterogeneous palladium and platinum mixed catalyst
Ito, Nobuhiro,Watahiki, Tsutomu,Maesawa, Tsuneaki,Maegawa, Tomohiro,Sajiki, Hironao
, p. 1467 - 1478 (2008/12/21)
An effective and applicable deuteration method for alkyl-substituted aromatic compounds using a heterogeneous Pd/C and Pt/C mixed catalyst in deuterium oxide in the presence of a small amount of hydrogen gas was developed. Mixing a heterogeneous palladium
