861429-73-4Relevant academic research and scientific papers
Glutamic acid analogues as potent dipeptidyl peptidase IV and 8 inhibitors
Lu, I-Lin,Lee, Shiow-Ju,Tsu, Hsu,Wu, Su-Ying,Kao, Kuo-His,Chien, Chia-Hui,Chang, Ying-Ying,Chen, Yuan-Shou,Cheng, Jai-Hong,Chang, Chung-Nien,Chen, Tung-Wei,Chang, Sheng-Ping,Chen, Xin,Jiaang, Weir-Torn
, p. 3271 - 3275 (2007/10/03)
To find potent and selective inhibitors of dipeptidyl peptidase IV (DPP-IV), we synthesized a series of 2-cyanopyrrolidine with P2-site 4-substituted glutamic acid derivatives and tested their activities against DPP-IV, DPP8, and DPP-II. Analogues that in
