861445-46-7

Upstream product

• 380886-36-2 (R)-tert-butyl 2-((1,3-dioxoisoindolin-2-yl)oxy)propanoate 
• 65864-22-4 (S)-2-amino-3-phenylpropionamide hydrochloride 
• 310404-43-4 (R)-2-phthalimidooxypropanoic acid 

Downstream Products

• 861445-50-3 [(S)-2-{(S)-2-[(R)-1-((S)-1-Carbamoyl-2-phenyl-ethylcarbamoyl)-ethoxycarbamoyl]-pyrrolidin-1-yl}-1-(4-hydroxy-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Structure-activity relationships of novel endomorphin-2 analogues with N-O turns induced by α-aminoxy acids

Endomorphin-2 (H-Tyr-Pro-Phe-Phe-NH2, EM-2) is a putative endogenous μ-opioid receptor ligand. To study the structure-activity relationship against its receptor, we introduced N-O turns into EM-2 and got the analogues with potent affinities for μ-opioid receptor. Our results indicated that N-O turn structures at the Pro2-aminoxy-Phe 3 position of EM-2 analogues played important roles for their affinities. These novel analogues with N-O turns provided a new approach to develop potent analgesics related to EM-2.