861446-17-5

Basic information

• Product Name: 3,5-bis(methoxymethoxy)benzoic chloride
• Synonyms: 3,5-bis(methoxymethoxy)benzoic chloride
• CAS NO: 861446-17-5
• Molecular Weight: 260.674
• Mol File: 861446-17-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3,5-bis(methoxymethoxy)benzoic chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-bis(methoxymethoxy)benzoic chloride(861446-17-5)
• EPA Substance Registry System: 3,5-bis(methoxymethoxy)benzoic chloride(861446-17-5)

Safety Data

• Hazardous Substances Data: 861446-17-5(Hazardous Substances Data)

Upstream product

• 1132-21-4 3,5-dimethoxybenzoic acid 
• 99-10-5 3,5-Dihydroxybenzoic acid 
• 228997-09-9 3,5-bis(methoxymethoxy)benzoic acid 

Downstream Products

• 35354-29-1 3,5-diacetoxybenzoic acid 
• 861446-18-6 3,5-bis(methoxymethoxy)-4'-acetoxy stilbene 

Relevant articles and documents

Synthesis of 4′-ester analogs of resveratrol and their evaluation in malignant melanoma and pancreatic cell lines

4′-Ester analogs of the disease preventative agent resveratrol were synthesized and evaluated for their potential as anti-melanoma and pancreatic cancer agents. A decarbonylative Heck coupling was used to assemble the protected stilbene core structure. Th

Synthesis of polyhydroxylated ester analogs of the stilbene resveratrol using decarbonylative Heck couplings

Protected 3,5-hydroxy-benzoyl chlorides 3 were coupled with styrenes 4 to give hydroxylated stilbenes, analogs of resveratrol, an important antioxidant disease preventative agent isolated from grape skins and other dietary sources. Levulinate and chloroacetate protecting groups allowed for the selective production of mono- and di-acetate variations under palladium-N-heterocyclic carbene (NHC) catalyzed decarbonylative coupling conditions. Fluorinated analogs were also produced using Heck conditions with bromofluorobenzenes. Human HL-60 cell assays showed the 4′-acetoxy variant 11 to have improved activity (ED50 17 μM) relative to resveratrol (24 μM).