861542-95-2Relevant academic research and scientific papers
Synthesis of new 3-arylisoquinolinamines: Effect on topoisomerase I inhibition and cytotoxicity
Cho, Won-Jea,Min, Sun Young,Le, Thanh Nguyen,Kim, Tae Sung
, p. 4451 - 4454 (2003)
To investigate the structure-activity relationships of 3-arylisoquinolines, diverse substituted 3-aryisoquinolinamines were synthesized and tested in vitro antitumor activity against four tumor cell lines. Some of the compounds showed potent topoisomerase I inhibitory activity. Docking study of 7d with topoisomerase I-DNA complex was also performed.
