861632-58-8

Basic information

• Product Name: 7-(4-chlorobenzylidene)-4-(4-chlorophenyl)-3,4,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-2(5H)-one
• Synonyms: 7-(4-chlorobenzylidene)-4-(4-chlorophenyl)-3,4,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-2(5H)-one
• CAS NO: 861632-58-8
• Molecular Weight: 371.266
• Mol File: 861632-58-8.mol

Chemical Properties

• CAS DataBase Reference: 7-(4-chlorobenzylidene)-4-(4-chlorophenyl)-3,4,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-2(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(4-chlorobenzylidene)-4-(4-chlorophenyl)-3,4,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-2(5H)-one(861632-58-8)
• EPA Substance Registry System: 7-(4-chlorobenzylidene)-4-(4-chlorophenyl)-3,4,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-2(5H)-one(861632-58-8)

Safety Data

• Hazardous Substances Data: 861632-58-8(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 120-92-3 cyclopentanone 
• 57-13-6 urea 

Relevant articles and documents

Potassium phthalimide: An efficient and green organocatalyst for the synthesis of 4-aryl-7-(arylmethylene)-3,4,6,7-tetrahydro-1H-cyclopenta[d] pyrimidin-2(5H)-ones/thiones under solvent-free conditions

An efficient synthesis of Biginelli-type compounds using potassium phthalimide as a green, mild, and commercially available organocatalyst in a one-pot, multi-component cyclocondensation reaction of cyclopentanone, aldehydes, and urea/thiourea is reported

Application of O-sulfonic acid poly(4-vinylpyrrolidonium) chloride as an efficient polymer-supported catalyst in the rapid synthesis of 2H-indazolo[2,1-b]phthalazine-triones and Biginelli-like products

In this work, a series of 2H-indazolo[2,1-b]phthalazine-triones and Biginelli-like products were efficiently synthesized for the first time using O-Sulfonic acid poly(4-vinylpyrrolidonium) chloride ([PVP-SO3H]Cl) as an eco-friendly polymer-supp

PEG-SANM nanocomposite: A new catalytic application towards clean and highly efficient Biginelli-like reaction under solvent-free conditions

A series of pyrimidinone derivatives were efficiently synthesized using PEG-SANM nanocomposite as the solid acid nanocatalyst under mild and solvent-free conditions. The generality of the process was successfully demonstrated by variation of the starting

Bronsted acidic ionic liquid [C3SO3HDoim]HSO4 catalyzed one-pot three-component Biginelli-type reaction: An efficient and solvent-free synthesis of pyrimidinone derivatives and its mechanistic study

A series of Bronsted acidic ionic liquids (ILs) were prepared and used for Biginelli-type condensation reaction among aromatic aldehydes, urea or thiourea and cyclopentanone. Through this reaction, the synthesis of various pyrimidinones could be achieved. Of interest, it was found that the reaction was efficiently catalyzed by a novel, eco-friendly functionalized IL [C3SO3HDoim]HSO4, which could be reused for at least 7 times without significantly loss of catalytic activity. The reaction proceeded efficiently at 80 °C to afford the desired products in good yield (up to 96%). In addition, a possible mechanism that accounted for the IL [C3SO3HDoim]HSO4-catalyzed reaction was proposed.

Ga(OTf)3 catalyzed synthesis of 1,4-dihydropyrimidin-2(1H)-ones

Gallium(III) triflate was used to catalyze Biginelli-like reactions under solvent-free condition to obtain dihydropyrimidinone derivatives in good to excellent yields and short reaction time.

Synthesis of Pyrimidinone and 5-unsubstituted 4, 6-diarylpyrimidine-2(1H)-ones by Using Nano Magnetic Catalyst under Solvent Free Condition

Nano magnetic-supported sulfonic acid is found to be a powerful and reusable heterogeneous catalyst for the efficient synthesis of pyrimidinones. In this study we use various ketones such as acetophenone and cyclopentanone instead of β-keto ester in one-p

Nano titania-supported sulfonic acid: An efficient and reusable catalyst for a range of organic reactions under solvent free conditions

Nano titania-supported sulfonic acid (n-TSA) has been easily prepared from the reaction of nano titania (titanium oxide) with chlorosulfonic acid as sulfonating agent and characterized by the FT-IR spectroscopy, scanning electron microscopy (SEM), X-ray diffraction (XRD) and thermal gravimetric analysis (TGA). The catalytic activity of n-TSA was investigated in the synthesis of important organic derivatives such as pyrimidones, benzothiazoles and chalcones. All of the reactions are very fast and the yields are good to excellent. The catalyst was easily separated and reused for several runs without appreciable loss of its catalytic activity.

Synthesis of substituted pyrimidinones catalyzed by boric acid and glycerol in aqueous medium

An expeditious one-pot synthesis of substituted pyrimidinone derivatives with aromatic aldehydes, cyclopentanone, and urea (or thiourea) was developed with boric acid (10mol%) and glycerol (0.1mL) in aqueous medium at 45-50 C. The methodology is simple, h

Bronsted acidic ionic liquid as an efficient and reusable catalyst for one-pot, three-component synthesis of pyrimidinone derivatives via biginelli-type reaction under solvent-free conditions

A mild and efficient method has been developed for the preparation of pyrimidinone derivatives from the reaction of aromatic aldehydes with cyclopentanone and urea or thiourea in the presence of N-(4-sulfonic acid) butyl triethyl ammonium hydrogen sulfate

An efficient and environmentally friendly procedure for synthesis of pyrimidinone derivatives by use of a Biginelli-type reaction

A Biginelli-type three-component reaction involving cyclopentanone, aromatic aldehyde, and urea or thiourea for preparation of pyrimidinone derivatives under neat conditions is described. This condensation reaction can also take place smoothly in the pres