861633-18-3

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 120-92-3 cyclopentanone 
• 57-13-6 urea 

Relevant academic research and scientific papers

Nano titania-supported sulfonic acid: An efficient and reusable catalyst for a range of organic reactions under solvent free conditions

Nano titania-supported sulfonic acid (n-TSA) has been easily prepared from the reaction of nano titania (titanium oxide) with chlorosulfonic acid as sulfonating agent and characterized by the FT-IR spectroscopy, scanning electron microscopy (SEM), X-ray diffraction (XRD) and thermal gravimetric analysis (TGA). The catalytic activity of n-TSA was investigated in the synthesis of important organic derivatives such as pyrimidones, benzothiazoles and chalcones. All of the reactions are very fast and the yields are good to excellent. The catalyst was easily separated and reused for several runs without appreciable loss of its catalytic activity.

A regioselective biginelli-like reaction controlled by the size of alicyclic mono-ketones

A regioselective Biginelli-like reaction of alicyclic mono-ketones, aromatic aldehydes, and urea in ionic liquid [BPY]BF4 has been investigated. The process is controlled by the size of alicyclic mono-ketones and the steric hindrance of aromatic aldehydes. The reaction of cyclopentanone with urea and aromatic aldehydes afforded 7-arylidene-3,4,6,7-tetrahydro-4-aryl- 1H-cyclopenta[d]pyrimidin-2(5H)-ones (4). When cyclohexanone was used as the source of active methylene to react with urea and aldehydes with slight steric hindrance groups under the same condition, 8-arylidene-3,4,5,6,7, 8-hexahydro-4-arylquinazolin-2(1H)-ones (6), a homologue of 4, were yielded, whereas 4,8-bisaryloc-tahydro-1H-pyrimido[5,4-i]-quinazoline-2,10(3H,11H)-diones (7) were obtained via the simple one-pot reaction of cyclohexanone, urea, and aromatic aldehydes with high steric hindrance groups. The possible transitional states and mechanism of the regioselective process were discussed.

Bronsted acidic ionic liquid as an efficient and reusable catalyst for one-pot, three-component synthesis of pyrimidinone derivatives via biginelli-type reaction under solvent-free conditions

A mild and efficient method has been developed for the preparation of pyrimidinone derivatives from the reaction of aromatic aldehydes with cyclopentanone and urea or thiourea in the presence of N-(4-sulfonic acid) butyl triethyl ammonium hydrogen sulfate

Microwave-assisted bronsted acidic ionic liquid-promoted one-pot synthesis of heterobicyclic dihydropyrimidinones by a three-component coupling of cyclopentanone, aldehydes, and urea

(Chemical Equation Presented) A simple and efficient method has been developed for the synthesis of heterobicyclic dihydropyrimidinone derivatives through a solvent-free one-pot three-component condensation of aromatic aldehydes, cyclopentanone, and urea or thiourea in the presence of Bronsted acidic ionic liquid under microwave irradiation. The catalyst can be reused at least six times without any noticeable decrease in catalytic activity.

An efficient and environmentally friendly procedure for synthesis of pyrimidinone derivatives by use of a Biginelli-type reaction

A Biginelli-type three-component reaction involving cyclopentanone, aromatic aldehyde, and urea or thiourea for preparation of pyrimidinone derivatives under neat conditions is described. This condensation reaction can also take place smoothly in the pres

Efficient synthesis of pyrimidinone derivatives by ytterbium chloride catalyzed Biginelli-type reaction under solvent-free conditions

An efficient and clean method was developed for the one-pot synthesis of pyrimidinones by ytterbium chloride catalyzed Biginelli-type reaction of aromatic aldehyde, cyclopentanone, and urea or thiourea under solvent-free conditions.