86165-52-8

Upstream product

• 1068-55-9 isopropylmagnesium chloride 
• 103-26-4 Methyl cinnamate 
• 1888-75-1 isopropyllithium 
• 20515-15-5 methyl (2E)-4-methylpent-2-enoate 
• 2996-92-1 phenyl trimethylsiloxane 
• 103-26-4 methyl cinnamate 
• 102-92-1 cinnamoyl chloride 
• 75919-28-7 4-methyl-4-nitro-3-phenyl-pentanoic acid methyl ester 
• 186581-53-3 diazomethane 
• 920-39-8 isopropylmagnesium bromide 
• 16205-99-5 (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl cinnamate 

Downstream Products

• 133326-57-5 (+/-)-acetic acid-(1,1,4-trimethyl-3-phenyl-pentyl ester) 
• 108011-47-8 (+/-)-2,5-dimethyl-4-phenyl-hexan-2-ol 

Relevant academic research and scientific papers

Conjugate addition of organocopper reagents in dichloromethane to α,β-unsaturated esters

Organocopper reagents in conjunction with Lewis acid activators provide greater stability than traditional cuprate reagents while maintaining the reactivity needed for conjugate addition reactions in dichloromethane. Whereas cuprates engage in cross-coupl

Asymmetric 1,4-addition of aryltrialkoxysilanes to α,β-unsaturated esters and amides catalyzed by a chiral rhodium complex

A highly enantioselective 1,4-addition of aryltrialkoxysilanes to α,β-unsaturated esters and amides was successfully catalyzed by a chiral rhodium complex generated from [Rh(cod)(MeCN)2]BF4 and (S)-BINAP.

REGIOSPECIFIC ADDITION OF ORGANOCOPPER REAGENTS TO α,β-UNSATURATED ESTERS

Mixed cuprates ArSCu(RMgX)n add rapidly to crotonates and cinnamates to give high yields of Michael adducts.Cuprates of methyl, ethyl, isopropyl, t-butyl, phenyl and vinyl were used.Crotonates give much higher yields of adducts with cuprates using 2-methoxythiophenoxide as a ligand than with those using thiophenoxide.

New Synthetic Methods. Conjugate Addition of Alkyl Groups to Electron Deficient Olefins with Nitroalkanes as Alkyl Anion Equivalents

The sequence of the Michael addition of nitroalkanes and denitration from the adduct provides a new and general method for conjugate addition of primary and secondary alkyl groups to electron deficient olefins such as α,β-unsaturated aldehydes, ketones, esters, nitriles, sulfoxides, and sulfones.

Reaction of Grignard Reagents with Benzaldehyde, 2,2-Dimethylpropanal and Cinnamates of Chiral Alcohols in Chiral Solvents

The asymmetric induction in a Grignard reaction carried out in (-)-1-isopropyl-2-methoxy-4-methylcyclohexane was higher than in the reaction carried out in (+)-1-methoxy-2-methylbutane.The chirality of the solvent contributed more than that of the reagent stereodifferentiation in the reaction of (+)-2-methylbutylmagnesium bromide with benzaldehyde in (+)-1-methoxy-2-methylbutane.