861710-03-4

Basic information

• Product Name: 4-CYANO-3,5-DIFLUOROPHENYLBORONIC ACID
• Synonyms: 4-CYANO-3,5-DIFLUOROPHENYLBORONIC ACID
• CAS NO: 861710-03-4
• Molecular Formula: C₇H₄BF₂NO₂
• Molecular Weight: 182.92
• Mol File: 861710-03-4.mol

Chemical Properties

• Appearance: /
• Density: 1.44
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Acetone (Slightly), DMSO (Slightly)
• CAS DataBase Reference: 4-CYANO-3,5-DIFLUOROPHENYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CYANO-3,5-DIFLUOROPHENYLBORONIC ACID(861710-03-4)
• EPA Substance Registry System: 4-CYANO-3,5-DIFLUOROPHENYLBORONIC ACID(861710-03-4)

Safety Data

• Hazardous Substances Data: 861710-03-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
4-Cyano-3,5-difluorophenylboronic acid is used as a reagent for introducing phenyl and phenyl derivative groups into compounds, which is crucial in the synthesis of various pharmaceutical compounds. Its role in coupling reactions, a common type of reaction in this field, makes it an essential component in the development of new drugs.
Used in Organic Synthesis:
In the field of organic synthesis, 4-Cyano-3,5-difluorophenylboronic acid is used as a key intermediate for the preparation of various organic compounds. Its ability to form carbon-carbon bonds through the Suzuki reaction, a popular method in this area, contributes to the synthesis of complex molecules with potential applications in various industries.
Used in Chemical Research:
4-Cyano-3,5-difluorophenylboronic acid is employed as a research tool in chemical studies, where its stable structure and high reactivity are utilized to explore new reaction pathways and mechanisms. This helps in advancing the understanding of chemical processes and the development of novel synthetic strategies.

Upstream product

• 1003298-73-4 2,6-difluoro-4-(4,4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 

Downstream Products

• 1227911-55-8 (3S,6R)-1-[6-(4-cyano-3,5-difluorophenyl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide 
• 1227911-57-0 (3S,6R)-1-[6-(4-cyano-3,5-difluorophenyl)-2-(methylamino)-4-pyrimidinyl]-6-methyl-N-(phenylmethyl)-3-piperidinecarboxamide 

Relevant articles and documents

BENZIIMIDAZOLE AND IMIDAZOPYRIDINE DERIVATIVES AS SODIUM CHANNEL MODULATORS

The invention relates to benzimidazole and imidazopyridine derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to new Nav1.8 modulators of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7. X and Y are as defined in the description. Nav1.8 modulators are potentially useful in the treatment of a wide range of disorders, particularly pain.

CHEMICAL COMPOUNDS

The invention is directed to 6-(4-pyι?midinyl)-1 H-indazole derivatives. Specifically, the invention is directed to compounds according to Formula (I) wherein R1 - R4 are defined herein. The compounds of the invention are inhibitors of PDK1 and can be useful in the treatment of immune and metabolic diseases and disorders characterized by constitutively activated ACG kinases such as cancer and more specifically cancers of the breast, colon, and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PDK1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.