86176-56-9

Basic information

• Product Name: 4-CHLORO-2-(ISOXAZOL-5-YL)PHENOL
• Synonyms: 4-CHLORO-2-(5-ISOXAZOLYL)PHENOL;4-CHLORO-2-(ISOXAZOL-5-YL)PHENOL;5-(5'-CHLORO-2'-HYDROXYPHENYL)-ISOXAZOLE;5-(5-CHLORO-2-HYDROXYPHENYL)-ISOXAZOLE;5-(2`-hydroxy-5`-chlorophenyl)isoxazole;2-(5-Isoxazole)-4-Chlorophenol
• CAS NO: 86176-56-9
• Molecular Formula: C₉H₆ClNO₂
• Molecular Weight: 195.6
• Product Categories: Isoxazoles, Oxadiazoles, Oxazoles
• Mol File: 86176-56-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 200-204°C
• Boiling Point: 353.989°C at 760 mmHg
• Flash Point: 167.887°C
• Appearance: /
• Density: 1.386g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: 4-CHLORO-2-(ISOXAZOL-5-YL)PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-(ISOXAZOL-5-YL)PHENOL(86176-56-9)
• EPA Substance Registry System: 4-CHLORO-2-(ISOXAZOL-5-YL)PHENOL(86176-56-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 86176-56-9(Hazardous Substances Data)

Usage

General Description

4-CHLORO-2-(ISOXAZOL-5-YL)PHENOL is a chemical compound with the molecular formula C9H6ClNO2. It is a white to light yellow crystalline powder that is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. The compound contains a chloro and isoxazolyl group attached to a phenol ring, making it a potentially useful building block in organic synthesis. Additionally, it has been found to exhibit antimicrobial and antifungal properties, and may have potential applications in the development of new drugs or pesticides. However, its specific uses and potential hazards should be further evaluated through research and testing.

InChI:InChI=1/C9H6ClNO2/c10-6-1-2-8(12)7(5-6)9-3-4-11-13-9/h1-5,12H

Upstream product

• 73220-32-3 C₁₁H₁₂ClNO₂ 
• 1450-74-4 5-chloro-2-hydroxyacetophenone 
• 73220-32-3 (2E)-1-(5-chloro-2-hydroxyphenyl)-3-(dimethylamino)-2-propen-1-one 
• 33533-99-2 6-chloro-4H-chromen-4-one 

Downstream Products

• 1233227-88-7 5-[2-(3-Bromo-propoxy)-5-chloro-phenyl]-isoxazole 
• 787575-65-9 (4-chloro-2-isoxazol-5-yl-phenoxy)-acetic acid methyl ester 
• 519173-08-1 2-(4-chloro-2-isoxazol-5-yl-phenoxy)-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone 

Relevant articles and documents

Reactions of 3-(polyfluoroacyl)chromones with hydroxylamine. The first synthesis of 3-cyano-2-(polyfluoroalkyl)chromones

Reaction of 3-(polyfluoroacyl)chromones with hydroxylamine proceeds via nucleophilic 1,4-addition followed by opening of the pyrone ring and subsequent cyclization to 4-(polyfluoroalkyl)-4H-chromeno[3,4-d]isoxazol-4-ols in good yields. On treatment with trifluoroacetic acid, the isoxazole ring of this annulated heterocyclic system opens to give 3-cyano-2-(polyfluoroalkyl)chromones. Reaction of 3-(polyfluoroacyl)chromones with hydroxylamine hydrochloride occurs only at the carbonyl carbon atom connected to the RF group to give the corresponding oximes in low yields.

Novel Bicyclic Pyridinones

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Synthesis of substituted isoxazoles and 1,3,4-oxadiazoles

A few novel 5-(2'-hydroxyaryl)-isoxazoles 3 and 2-(aryloxymethyl)-3-mercapto-1,3,4-oxadiazoles 8 have been synthesized from the intermediate enamino ketones 2, and tested for their herbicidal activity