86176-56-9

Usage

Uses

Used in Pharmaceutical Synthesis:
4-CHLORO-2-(ISOXAZOL-5-YL)PHENOL is used as an intermediate in the pharmaceutical industry for its potential role in the development of new drugs. Its unique structure allows it to be a key component in the synthesis of various medicinal compounds.
Used in Agrochemical Synthesis:
In the agrochemical sector, 4-CHLORO-2-(ISOXAZOL-5-YL)PHENOL serves as an intermediate, contributing to the creation of new pesticides. Its properties may enhance the effectiveness of these products in agricultural applications.
Used in Organic Synthesis:
4-CHLORO-2-(ISOXAZOL-5-YL)PHENOL is utilized as a building block in organic synthesis, where its chloro and isoxazolyl groups attached to a phenol ring provide versatility for creating a range of organic compounds.
Used in Antimicrobial and Antifungal Applications:
4-CHLORO-2-(ISOXAZOL-5-YL)PHENOL has been found to exhibit antimicrobial and antifungal properties, suggesting its potential use in the development of new treatments or preventive measures against microbial and fungal infections.

InChI:InChI=1/C9H6ClNO2/c10-6-1-2-8(12)7(5-6)9-3-4-11-13-9/h1-5,12H

Upstream product

• 33533-99-2 6-chloro-4H-chromen-4-one 
• 73220-32-3 C₁₁H₁₂ClNO₂ 
• 1450-74-4 5-chloro-2-hydroxyacetophenone 
• 73220-32-3 (2E)-1-(5-chloro-2-hydroxyphenyl)-3-(dimethylamino)-2-propen-1-one 

Downstream Products

• 519173-08-1 2-(4-chloro-2-isoxazol-5-yl-phenoxy)-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone 
• 1233227-88-7 5-[2-(3-Bromo-propoxy)-5-chloro-phenyl]-isoxazole 
• 787575-65-9 (4-chloro-2-isoxazol-5-yl-phenoxy)-acetic acid methyl ester 

Relevant academic research and scientific papers

Reactions of 3-(polyfluoroacyl)chromones with hydroxylamine. The first synthesis of 3-cyano-2-(polyfluoroalkyl)chromones

Reaction of 3-(polyfluoroacyl)chromones with hydroxylamine proceeds via nucleophilic 1,4-addition followed by opening of the pyrone ring and subsequent cyclization to 4-(polyfluoroalkyl)-4H-chromeno[3,4-d]isoxazol-4-ols in good yields. On treatment with trifluoroacetic acid, the isoxazole ring of this annulated heterocyclic system opens to give 3-cyano-2-(polyfluoroalkyl)chromones. Reaction of 3-(polyfluoroacyl)chromones with hydroxylamine hydrochloride occurs only at the carbonyl carbon atom connected to the RF group to give the corresponding oximes in low yields.

Zn(OTf)2-Catalyzed Formal [3 + 3] Cascade Annulation of Propargylic Alcohols with 2-Aminochromones: Accessing the Chromeno[2,3- b]pyridines

A Zn(OTf)2-catalyzed formal [3 + 3] cascade annulation strategy for the synthesis of functionalized chromeno[2,3-b]pyridines has been developed using propargylic alcohols and 2-aminochromones as the substrates. The protocol provides a convenien

Novel Bicyclic Pyridinones

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Synthesis of 2,2′-diaminobischromones using a modified procedure for the rearrangement of 5-(2-hydroxyphenyl)isoxazole to 2-aminochromone

A modified procedure for the rearrangement of 5-(2-hydroxyphenyl)isoxazoles 6a-e to 2-aminochromones 8a-e was developed and this procedure was utilised in the synthesis of hitherto unreported bischromones 3a-c. The isoxazoles 6a-e were prepared regioselec

Synthesis of substituted isoxazoles and 1,3,4-oxadiazoles

A few novel 5-(2'-hydroxyaryl)-isoxazoles 3 and 2-(aryloxymethyl)-3-mercapto-1,3,4-oxadiazoles 8 have been synthesized from the intermediate enamino ketones 2, and tested for their herbicidal activity

A NEW PATHWAY IN THE REACTIONS OF CHROMONES AND HYDROXYLAMINE IN ANHYDROUS SOLUTIONS

In the nucleophilic reaction of chromone (1) with NH2OH.HCl in anhydrous methanol a new compound 2-methoxychromanone (6) appeared as an intermediate in the formation of chromone oxime (8) and 2-methoxychromanone oxime (7).

Fungicidal isoxazolyl phenols and method of use

A compound of the formula: STR1 wherein X is a member selected from the group consisting of hydrogen, alkyl of from 1 to 3 carbon atoms, inclusive, chlorine or bromine; Y is a member selected from the group consisting of hydrogen, chlorine or bromine and