86180-54-3Relevant academic research and scientific papers
Synthesis, characterization, and copper(II) chelates of 1,11-dithia-4,8-diazacyclotetradecane
Taschner, Ian S.,Walker, Tia L.,Dehaan, Hunter S.,Schrage, Briana R.,Ziegler, Christopher J.,Taschner, Michael J.
, p. 11091 - 11102 (2019/09/30)
Synthesis of 1,11-dithia-4,8-diazacyclotetradecane (L1), a constitutional isomer of the macrocyclic [14]aneN2S2 series, is accompanied with reaction and method optimization. Chelation of L1 with copper(II) provided assessment of latt
Palladium nanoparticles in glycerol: A versatile catalytic system for C-X bond formation and hydrogenation processes
Chahdoura, Faouzi,Pradel, Christian,Gomez, Montserrat
supporting information, p. 3648 - 3660 (2014/01/06)
Palladium nanoparticles stabilised by tris(3-sulfophenyl)phosphine trisodium salt in neat glycerol have been synthesised and fully characterised, starting from both Pd(II) and Pd(0) species. The versatility of this innovative catalytic colloidal solution has been proved by its efficient application in C-X bond formation processes (X=C, N, P, S) and C-C multiple bond hydrogenation reactions. The catalytic glycerol phase could be recycled more than ten times, preserving its activity and selectivity. The scope of each of these processes has demonstrated the power of the as-prepared catalyst, isolating the corresponding expected products in yields higher than 90%. The dual catalytic behaviour of this glycerol phase, associated to the metallic nanocatalysts used in wet medium (molecular- and surface-like behaviour), has allowed attractive applications in one-pot multi-step transformations catalysed by palladium, such as C-C coupling followed by hydrogenation, without isolation of intermediates using only one catalytic precursor. Copyright
Novel synthesis of methyl ketones based on the blaise reaction
Rao, H. Surya Prakash,Padmavathy,Vasantham,Rafi, Shaik
body text, p. 1825 - 1834 (2009/10/02)
A facile two-step synthesis of methyl ketones from alkyl nitriles via the Blaise conversion of nitriles into -keto esters and acid-mediated hydrolysis followed by decarboxylation of the resulting -keto esters is described. Copyright Taylor & Francis Group, LLC.
RuCl3 in poly(ethylene glycol): A highly efficient and recyclable catalyst for the conjugate addition of nitrogen and sulfur nucleophiles
Zhang, Huaxing,Zhang, Yuhong,Liu, Leifang,Xu, Hailiang,Wang, Yanguang
, p. 2129 - 2136 (2007/10/03)
The 1,4-conjugate addition of primary, secondary and aromatic amines, thiols, and carbamate to α,β-unsaturated compounds mediated by a catalytic amount (0.5 mol%) of RuCl3 in poly(ethylene glycol) (PEG) provides the desired β-substituted carbonyls in high yields. In particular, we found that primary aliphatic and aromatic amines produced the single adducts as the sole products in very high yields with RuCl3-PEG. RuCl 3-PEG was readily recycled via solvent precipitation with efficient recyclability as evidenced by high yields. Its properties of low sensitivity toward moisture and oxygen, high tolerance of different functional groups, and efficient recyclability make RuCl3-PEG suitable for both laboratory and industrial scale synthesis of β-substituted carbonyls. Georg Thieme Verlag Stuttgart.
Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV- 2 replication by antagonism of the chemokine receptor CXCR4
Bridger, Gary J.,Skerlj, Renato T.,Padmanabhan, Sreenivasan,Martellucci, Stephen A.,Henson, Geoffrey W.,Struyf, Sofie,Witvrouw, Myriam,Schols, Dominique,De Clercq, Erik
, p. 3971 - 3981 (2007/10/03)
Bis-tetraazamacrocycles such as the bicyclam AMD3100 are a class of potent and selective anti-HIV-1 and HIV-2 agents that inhibit virus replication by binding to the chemokine receptor CXCR4, the co-receptor for entry of X4 viruses. With the aim of optimi
