861804-17-3Relevant academic research and scientific papers
Synthesis and binding affinity of novel 3-aminoethyl-1-tetralones, potential atypical antipsychotics
Alvarado, Mario,Coelho, Alberto,Masaguer, Christian F.,Ravina, Enrique,Brea, Jose,Padin, J. Fernando,Loza, Maria I.
, p. 3063 - 3066 (2007/10/03)
A series of 3-aminoethyl-1-tetralones, conformationally constrained higher homologues of haloperidol (standard for typical antipsychotic profile), have been obtained by a four-step route from valerolactone. Their binding affinities at dopamine D2 and serotonin 5-HT2A and 5-HT2C receptors were determined, showing in some cases an atypical antipsychotic profile.
