861821-42-3Relevant articles and documents
Concise and practical synthesis of latrunculin A by ring-closing enyne-yne metathesis
Fuerstner, Alois,Turet, Laurent
, p. 3462 - 3466 (2005)
(Chemical Equation Presented) Selective actin-binding is the most prominent biochemical property of the scarce marine natural product latrunculin A (see formula). Modern metal-catalyzed C-C bond-formation reactions, including a ring-closing enyne-yne metathesis (shown in red), now open a convenient, flexible, and productive entry to this important probe molecule for chemical biology.